Treatment of diseases of the digestive system in pets is difficult and does not always lead to a positive result. Of particular danger is pancreatitis - a pathology of the pancreas, accompanied by indigestion, severe pain, vomiting, exhaustion, and in severe cases - death of organ cells. Special means are used for treatment. The drug Gordox for cats will help relieve the animal from unpleasant symptoms.
Description and main properties
Pancreatitis is inflammation of the cells of the pancreas. This organ is responsible for the production of digestive enzymes that enter the intestines and insulin, a hormone that enters the blood.
Typically, the disease develops as a result of an excess of fatty foods in the animal’s diet, which is accompanied by excess weight and accumulation of fat in the blood. The cause of the disease may be concomitant diseases such as diabetes mellitus, hyperthyroidism, existing malignant neoplasms, or the use of certain medications.
Pancreatitis is accompanied by frequent repeated vomiting, loss of appetite or complete refusal of food, pain when palpating the abdomen, weakness, dehydration and stool disturbances.
For pancreatitis, a drug is used that reduces the formation of damage to the pancreas as a result of the formation of enzymes during the next exacerbation - Gordox for cats. The instructions for use must be read before using the drug.
The drug has hemostatic, antiproteolytic and antifibrinolytic properties. It is widely used to reduce bleeding caused by high levels of blood clot-dissolving substances during surgery.
Indications and contraindications for use
The drug may be prescribed for the following cases:
- for bleeding (due to injury, surgery, childbirth);
- exacerbation of pancreatitis or its acute forms;
- shock of various etiologies;
- significant and numerous injuries, fractures.
Most often, the reason for taking the medicine is acute conditions of pancreatitis. The animal tolerates them with difficulty - vomiting is observed, including on an empty stomach, lethargy, dehydration, bowel problems (diarrhea or constipation). "Gordox" helps relieve these symptoms. The cat is prescribed the necessary examination (ultrasound, blood test) and the cause of the disease is looked for. Treatment is usually prescribed comprehensively with obligatory adherence to a diet.
Contraindications to the use of Gordox are allergies to its components, pregnancy and lactation of the cat.
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Mechanism of action
Aprotinin weakens the process of inflammation of the pancreas and increases blood clotting, which is very important during surgical operations. It is a polypeptide compound that affects the production of trypsin, plasmin and kallidogenase.
The active substance has antiproteolytic and hemostatic properties, which make it possible to delay the formation of kallikrein in the body.
After application, the drug is very quickly distributed in the intercellular space of tissues, which leads to a decrease in its amount in the blood plasma. The effect of the drug begins 0.4−0.8 hours after intravenous administration. The active substance accumulates in the epithelial cells of the kidneys, cartilage tissue and in the brain.
Metabolism occurs in the kidneys, and the remaining drug is excreted in the urine within 10 hours.
Indications for use
Gordox is used strictly as prescribed by the attending physician. It is used if the animal is diagnosed with the following diseases:
- acute and chronic pancreatitis;
- pancreatic necrosis;
- bleeding caused by hyperfibrinolysis in the postoperative period or after childbirth;
- polymenorrhea;
- angioedema;
- toxic, traumatic and hemorrhagic shock;
- diagnostic measures on the pancreas;
- extensive soft tissue damage to increase blood clotting;
- prevention of postoperative nonspecific parotitis.
Instructions for use
The drug is intended for intravenous or subcutaneous administration using a catheter or syringe into the interscapular area. For effective treatment, it is recommended to start using Gordox at the initial stage of the disease. In this case, the drug is used for a long time in high doses.
The dosage of the product is selected by a specialist for each animal individually after a diagnostic examination.
Considering that the active substance can cause the development of an allergic reaction, a test dose of 1 ml should be administered. If no adverse reactions occur after the injection, then the therapeutic dose is administered in full. To avoid the development of allergies, the cat can be given an antihistamine 30 minutes before the medication is administered.
The dosage of Gordox for cats, according to the instructions for use, is selected taking into account the weight of the pet. The following amount of the drug is used for treatment:
- up to 5 kg - 0.5 ml;
- 5−10 kg - 1 ml.
For larger animals, the doctor must calculate the dose of the medicine individually.
When treating acute pancreatitis, the drug is administered intravenously for the first two days. After the symptoms are relieved, when attacks of vomiting do not bother the cat, the solution is applied subcutaneously once a day. The duration of therapy is 5−7 days.
The drug should not be used to treat pregnant and lactating animals, since the effect of the active substance on the body has not been sufficiently studied.
Side effects
When using the drug "Gordox", the following side effects may occasionally occur:
- allergy;
- tachycardia;
- thrombophlebitis (with long-term use);
- renal failure;
- vomiting - happens when the drug is administered too quickly;
- psychosomatic reactions, confused perceptions and hallucinations are rare.
Contraindications and side effects
Gordox is not used if animals have individual intolerance to the components included in the drug.
The injection solution may cause the development of side effects, which are accompanied by the development of allergic and anaphylactic reactions. Cats may also experience the following symptoms:
- renal failure;
- cardiopalmus;
- disruption of the hematopoietic system, accompanied by the formation of blood clots.
If the first signs appear, stop using the drug. If any deviations in the animal’s condition occur, you should immediately contact a specialist.
Usually an allergy may be observed upon first use. With repeated use, the risk of its occurrence is small.
Pharmacological action of "Gordox"
Each component in the composition of the drug affects the body as follows: anti-proteolytic effect; action that reduces the fibrinolytic activity of the blood; hemostatic effect. After administration of the drug, the activity of the following enzymes decreases: trypsin; chymotrypsin; kiningenase; kallikrein. The activity of the main and individual proteolytic proteases (enzymes) decreases. This effect after use helps with lesions of the digestive organs, where there is an increased content of kallikrein and other elements in the blood and tissues. The active substance reduces fibrinolysis. Therefore, there is a hemostatic effect.
Security measures
Gordox is a low-toxic drug. However, when using it, precautions should be taken:
- for injections and intravenous infusions, use disposable syringes and catheters;
- Give injections using medical gloves;
- If the medicine gets on the skin, wash off any remaining medication with water;
- if the owner is at risk of developing an allergic reaction, take an antihistamine;
- Avoid contact of the medication with the eyes and mucous surfaces;
- Dispose of any remaining medication and packaging together with household waste.
The shelf life of Gordox is 5 years from the date of manufacture. The medication is stored in a dark, cool place, out of the reach of children, away from food and feed.
Analogues of the drug
If it is not possible to use Gordox for cats, it is replaced with a drug that has a similar effect. Currently, there are several analogues of the drug.
The following products have similar properties:
- Trasylol contains the active substance aprotinin and is used for the treatment of pancreatitis, diagnostic examinations of the pancreas and surgical operations. The medicine is indicated to stop post-traumatic and postoperative bleeding.
- Aprotex has a similar composition and has a similar effect.
Composition of the drug
The active component of Gordox is aprotinin, a special substance that helps to weaken inflammatory reactions in the pancreas and also helps to activate greater blood clotting, which is especially important for postoperative bleeding.
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In veterinary medicine, it is used after various surgical interventions, however, unauthorized treatment of cats with this drug can lead to many side effects, including death. Instructions for use of Gordox for cats and kittens are the very first thing you should read when handling this drug.
Owner reviews
Some time after eating, the cat began to vomit. At first I associated this with systematic overeating, but the vomiting was irregular. Later the animal began to lose weight. Her appetite has worsened. And after some time she completely refused to eat. The urine has turned orange. The fur became disheveled. The veterinary clinic recommended Gordox injections. They gave injections for three days. The condition was stabilized. The cat began to eat and became active.
Marina
We took an adult cat from the street. It turned out that he had a whole “bouquet” of diseases. The veterinarian diagnosed urolithiasis and liver damage caused by insufficient production of enzymes by the pancreas. Gordox was prescribed intravenously. I'm currently taking injections. The cat began to feel much better. I hope the medicine will help him.
Victoria
An effective remedy that is often prescribed for the treatment of acute and chronic pancreatitis.
The drug helps stop bleeding. I consider the large number of side effects to be a disadvantage, so I recommend using Gordox only after consulting a doctor. Svetlana Alekseevna, veterinarian
Storage conditions
The medication is in ampoules. Therefore, it is recommended to keep “Gordox” in a warm place with a temperature range of 15-30C. The medication must be stored in a dark place for up to 5 years. An open ampoule cannot be kept for long periods of time.
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The drug "Gordox" is produced by a well-known multinational pharmaceutical company with representatives in 40 countries. The drug affects the blood, the formation and development of blood cells, and inhibits the activity of pancreatic enzymes. The drug can be used for health problems in cats.
