Anthelmintic for cats up to 2.5 kg Bayer Profender, Drops on the withers, treatment and prevention of worms

Review of Profender for cats

• For cats weighing less than 2.5 kg – 0.35 ml;
• For cats weighing less than 5 kg – 0.7 ml;
• For cats weighing less than 8 kg – 1.12 ml.

• Nematodes
  – toxocariasis, toxascariasis, hookworm disease. These parasites belong to the class of roundworms that infect the intestines and respiratory organs of the cat (lungs, bronchi, trachea). They can also live in the thickness of cat skin, causing allergic reactions and itching. If worms have chosen the intestines, the pet may experience blood in the stool, anemia, and in special cases, intestinal obstruction. If the respiratory system is damaged, bronchitis, pulmonary failure, and pneumonia may develop;
• Cestodoses
  – dipylidiasis, taeniasis, echinococcosis. During the course of the disease, tapeworms fill the cat's small intestine, but if left untreated, the parasites can travel virtually throughout the body, affecting the cat's gastrointestinal tract, heart, liver, kidneys, eyes, and even the brain. In addition, most cestodes can migrate from cat to owner, causing many unpleasant consequences. Symptoms of cestodiasis include weight loss, emaciated appearance, constipation or diarrhea, and vomiting. Depending on the location of the worms, the cat may experience, for example, heart failure, tachycardia (if the heart is damaged), blindness (if the eyes are damaged), ascites (if the liver is damaged) and many other complications.

Composition and properties of the drug

"Profender" is produced by German. The medicine takes the form of drops that are used to treat the animal’s withers. The drug is applied using pipettes contained in the package.

The main active components of the product are:

• emodepsid. 1 ml of solution contains 21.4 mg. This is a peptide that has an antibiotic effect. Most effective against nematodes. It has a stimulating effect on latrophilin presynaptic receptors, provoking the death of parasites;
• Praziquantel 1 ml of solution contains 85.8 mg. This substance causes damage to neuromuscular connections, leading to the death of worms due to disruption of energy exchange processes. It also causes polarization of ganglion blockers. Most effective in the fight against cestodes.

As auxiliary components, this medicine contains substances that accelerate the absorption of active compounds in the animal's body.

After use, the active substances of the drops penetrate first into the pet’s blood and then into the cells of the parasites. Due to its prolonged effect, the medicine is effective 3-4 days after use. The activity of the main active components remains for a month.

The package contains the drug itself and two pipettes for it (sealed in a blister made of aluminum foil). There are also instructions inside the cardboard box.

Properties of the drug

Profender for cats in the form of drops is a combination medicine that is used to rid a pet of helminths. It contains components that can provide a wide range of anthelmintic effects.

The medicine affects round and tapeworms : Toxacara cati destroys both adult and larval stages, Toxascaris leonine, Dipylidium caninum, Taenia taeniaeformis.

Emodepside is a semi-synthetic compound of the depsipeptide group. Has strong nematocidal properties. It has an effect on the nerve cells of the parasite, causing paralysis.

Praziquantel is active against gastrointestinal cystodes at any stage of their development. It affects the muscle innervation of parasites, causing paralysis. It blocks the absorption of glucose in cystodes and they soon die.

The product is well absorbed into the body and remains for a long time, providing a long-lasting therapeutic effect. A high concentration of Praziquantel in the blood is observed within 2-4 days from the moment of application. The drug is eliminated from the body after 30 days. In terms of its effects on the body, Profender is a class III drug of moderate danger. Application of the recommended dose does not cause irritation. The product is well tolerated by cats.

Profender is prescribed to cats for the prevention and treatment of worms.

Drops for external use. Before applying to the skin, the protective cap is removed from the pipette and, positioned vertically, the protective membrane of the package is pierced. It is necessary to spread the hair at the withers; it must be applied to places where the cat cannot reach and lick the preparation. The best place for application is the area of ​​skin between the shoulder blades . When treating large cats, the drug is applied to the neck in several places.

The minimum dosage of Profender is 0.14 ml per 1 kilogram of cat weight.

Preventive measures using the drug Profender can be started from 8 weeks of age at the following dosage:

• 0.5-2.5 kg - Profender for kittens. Dosage 0.35 ml.
• 2.6-5 kg ​​- Profender for medium-sized cats. Dosage 0.7 ml.
• 5.1-8 kg - Profender for big cats. Dosage 1.2 ml.
• 8 kg and more - I use a combination of different packaging.

For cats weighing more than 8 kg, Profender is prescribed at a rate of 0.14 ml per kilogram of weight. For treatment against worms, a single application of the drug is carried out, but for prevention it can be applied quarterly.

The drug is absorbed within 2 hours. After this time, the cat can be washed if necessary.

In case of overdose, cats experience increased drowsiness, sometimes vomiting, and tremors. If you notice serious side effects, the area where the product is applied should be rinsed with water.

If the drug is applied according to the instructions, no side effects are observed. But in rare cases, there are individual reactions: redness, itching. They go away on their own without requiring the intervention of medications. If an allergic reaction occurs, rinse the drug thoroughly with running water. In case of severe reactions, antihistamines should be administered. The use of Profender together with other deworming agents is strictly prohibited.

Contraindications and side effects

The use of Profender strictly according to the instructions for the drug does not cause side effects. Among the contraindications is the age of the pet. The use of Profender for kittens is possible only from 2 months, provided that their weight is more than 500 g.

Pregnancy, lactation, rehabilitation after illness, which are contraindicated for other anthelmintics, will not be an obstacle for Profender.

However, the cat may have an individual intolerance to the components of the drug

Therefore, when using for the first time, strictly follow the dosage and pay attention to the following symptoms: itching and redness of the skin at the site of application. If they appear, it is better to refuse Profender in the future.

Side effects

Profender is a safe drug, when used correctly, it does not cause adverse reactions. In rare cases (detected in less than 10 animals out of a sample of 10,000 individuals), allergic reactions occur - itching, rash. In extremely rare cases (less than one animal out of a sample of 10,000 individuals), increased salivation, tremors of the limbs, and vomiting are possible. Symptoms go away on their own and do not require contacting a veterinarian.

If the drug gets on the mucous membranes, wash them with warm water and soap. This rule applies to the pet and its owner. If the drug has been swallowed by a person, you should consult a doctor.

Instructions for use

The procedure for using Profender is simple. It is necessary to take the required dose of medicine (remove the cap from the pipette and pierce its protective membrane), part the cat’s fur in the area of ​​the withers between the shoulder blades and squeeze the medicine onto the skin. The skin will absorb Profender in two hours. Be sure to make sure that your pet does not have the opportunity to reach the treatment site with his tongue. After using the pipette, immediately throw it in the trash, after wrapping it in a bag.

To perform the described procedure, it is necessary to calculate the dosage of the veterinary drug. The calculation is based on the weight of your cat in the following proportions:

• 0.5-2.5 kg - 0.35 ml;
• 2.5-5 kg ​​- 0.7 ml;
• 5-8 kg - 1.2 ml;
• over 8 kg - the dosage is determined at the rate of 0.14 ml/1 kg of the pet’s weight (you need to combine pipettes of different packaging).

After treating your pet, wash your hands thoroughly and limit access to small children. During the day, the cat should not be bathed, and during this time, the cat should not be stroked. The components of the drug are toxic to the human body if ingested and can cause reactions such as poisoning and intoxication. The treatment procedure is performed once per quarter.

Video about these drops:

Dosage and Method of Administration

Profender is sold in pipettes with markings indicating the amount of active substance in milliliters and recommendations for the weight of the animal, for example, “For small cats up to 2.5 kg.”

Veterinarians recommend adhering to the dosage indicated in the table:

* The dose is calculated depending on the weight of the pet - 0.14 mg per kg of animal body weight.

For example, to deworm a cat weighing 8.5 kg, you will need Profender in a dosage of 0.35 ml + 1.2 ml, for a cat weighing 11 kg - in a dosage of 1.2 ml + 0.7 ml.

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For treatment, Profender is used once. The drug is applied to the cat’s scruff, in a place inaccessible to licking, only on intact skin. For large animals, it is recommended to apply the product in several places.

Step-by-step instruction:

1. Remove the pipette from the packaging.
2. Remove the cap from it and pierce the protective membrane with it.
3. Using your hands, spread the fur on the cat’s back between the shoulder blades and drop Profender.

The pipette must be thrown into the trash; it must not be used for household purposes. Hands should be washed with soap after handling the cat.

The drug will be absorbed over the next 2 hours.

The cat should not be washed or stroked for the next 24 hours. We need to limit her access to small children.

To prevent the transmission of parasites through breast milk from cats to kittens, it is recommended to treat the animal 7 days before the expected birth.

To treat elurostrongylosis, the pet is treated twice with an interval of two weeks.

Contraindications

The veterinary drug is contraindicated for kittens under 8 weeks of age, as well as representatives of the cat breed whose weight does not exceed 0.5 kilograms. If the cat’s body does not tolerate the components that make up Profender, then the drops cannot be used in this case.

Another reason why treatment with the drug is contraindicated is kidney and liver diseases (chronic). It is allowed to use drops on pregnant cats and those nursing kittens. Just be sure to ensure that the latter do not have access to the area treated with the medicine.

Pharmacology

Profender drops for cats will be effective against cestodes and nematodes. This means that the use of drops is justified when infected with roundworms and tapeworms.

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The effect of the medicine is standard and practically no different from other means used for deworming. The components included in Profender affect the nervous system of the parasite, which provokes the development of paralysis and subsequent death. The helminth loses its ability to stay on the surface of the gastrointestinal mucosa and is released naturally: along with the feces. The use of laxatives in cats is not necessary.

The auxiliary composition "Profender" is represented by substances that accelerate the absorption of medicinal components. Maximum concentration is achieved after two to four days from the time of use of the product. The period during which the drug provides protection for the cat is 20–30 days. "Profender" is excreted along with urine, without having a toxic effect on the renal system.

According to the instructions, the medicine is moderately dangerous. This means that the use of Profender drops in recommended dosages does not cause skin irritation, does not cause a teratogenic or mutagenic effect on embryos, and does not affect the formation of immunity after the vaccination procedure.

Studies have shown that the cat’s body responds adequately to three times the permissible standard dosage of Profender.

Composition and release form of the drug

Emodepside (21.4 mg per 1 ml) and praziquantel (85.8 mg per 1 ml) are the two main active ingredients that are part of these anthelmintic drops. The effectiveness of the drug is due to the paralyzing effect on the cells of roundworms and tapeworms that these two components have. This impact leaves no chance for parasites to destroy them.

The antiparasitic drug is made in the form of a liquid solution, which is packaged in special pipettes of 2 pieces, and then in foil blisters. Next, the drug is packaged in boxes with instructions. The packaging comes in different volumes, since the amount of medicine used depends on the weight of the pet. Drops

They have a yellow or brown color and an unpleasant, pungent odor. If the drug is used correctly, this is perhaps the only negative.

The method of use is also specific - the drops are intended not for internal, but for external use. This means that there is no need to force the cat to swallow Profender. Usually this, as well as the use of tablets, is quite problematic. All you need to do is treat your pet’s skin at the withers. Within 3-4 days, the medicine will enter the bloodstream and have a beneficial effect on the body for a month.

Description of the drug Profender

Profender is a combination drug used in veterinary medicine for the treatment of helminthic infestations.
The generic name of the drug is emodepside, praziquantel. The developer of the unique form is the large German company Bayer Animal Health GmbH. Bayer is a world leader in the production of antiparasitic drugs

Profender is available in the form of drops on the withers in three modifications:

• for kittens and cats up to 2.5 kg;
• for cats 2.5–5 kg;
• for cats 5–8 kg.

The drops are a transparent yellow liquid, packaged in polymer pipettes with a volume of 0.35 ml, 0.7 ml and 1.12 ml. Pipettes, closed with caps, are packaged in metallized blisters (1 or 2 pieces each). Each blister is packed in a cardboard box with instructions for use.

Profender drops can be packaged in 2 types of packages. Russian-made drops are packaged in square gold boxes. And the drops, which are produced in Ukraine, are packaged in white rectangular boxes with a blue, pink or green pattern.

The color of the box and the colored stripe on the packaging indicate the modification of the drug (green - for small cats and kittens, blue - for medium-sized animals, red - for large cats and kittens)

Profender drops, which are produced in Russia, are packaged with recommendations in Russian. Most of the important information is indicated in the instructions and on the back of the box. The following is indicated on the blister (back side) and the pipette itself:

• name of the drug;
• modification of droplets;
• concentration of the active substance;
• series and release date;
• best before date;
• pipette volume.

The packaging blister is a soft container with a protective film

Composition of Profender

Profender drops (1 ml) consist of the following components:

• active ingredients (emodepside - 21.43 mg and praziquantel - 85.75 mg);
• butylhydroxyanisole - 5.4 mg (antioxidant, preservative);
• isopropylidene glycerol - 945.82 mg (a type of natural glycerin);
• lactic acid - 21.6 mg.

Profender drops are recommended to be stored under the following conditions:

• in sealed manufacturer's packaging;
• in a dry place, protected from direct sunlight;
• separately from food and feed;
• at temperatures from 0°C to 30°C;
• in places inaccessible to children.

If storage conditions are observed, the drug will be valid for 3 years from the date of release. After the expiration date, the drops must be disposed of (pipettes cannot be used for household purposes).

It is convenient to store all veterinary drugs in one first aid kit, but it is advisable to put particularly toxic drugs (for example, anthelmintics) in additional packaging (bag or container)

Precautionary measures

When working with the drug Profender, you must follow the rules of personal hygiene and safety precautions. Do not smoke or eat or drink water while applying the drug. After application, wash your hands thoroughly with soap and water. You should not touch or pet the cat for 24 hours.

If the medicine comes into contact with the eyes, they should be rinsed with plenty of water. People who have hypersensitivity to any component of Profender should avoid contact with animals or not participate in the application of the drug. If the drug enters the body, the person must contact a medical facility. It is advisable to take the drug with you for clarity, as well as instructions.

Used packaging must not be used for any other purpose or stored. It must be disposed of.

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Profender for cats

Description

Profender for cats 2 pipettes. A complex broad-spectrum anthelmintic for cats in the form of drops on the withers.

Profender is a complex anthelmintic drug. Profender contains emodepside and praziquantel as active ingredients, as well as auxiliary components (butylhydroxyanisole, isopropylidene glycerol, lactic acid). The drug is a transparent solution for external use from yellow to brown, 1 ml of which contains 21.4 mg of emodepside and 85.8 mg of praziquantel. The drug is produced packaged in 0.35 ml in polypropylene pipettes with caps, packed in aluminum blisters of 2 pieces, placed in cardboard boxes.

Indications

Profender is prescribed for deworming cats for prophylactic and therapeutic purposes for nematodes (toxocariasis, toxascariasis, hookworm) and cestodiasis (taeniasis, dipylidiasis, echinococcosis), by topical (drip) application of the drug to the skin.

Doses and method of administration

Before use, remove the protective cap from the pipette and, positioning it vertically, pierce the protective membrane of the pipette nose (putting the cap on the back side), then remove the cap again. The drug, by spreading the fur, is applied to places inaccessible for licking, directly on the skin between the shoulder blades at the base of the neck. The minimum therapeutic dose of Profender is 0.14 ml/kg of animal weight. Deworming of cats using Profender is carried out starting from 8 weeks of age, for therapeutic purposes - according to indications, for preventive purposes - quarterly.

Pharmacological properties

Profender has a wide spectrum of anthelmintic effect on round and tape helminths, including Toxocara sati, Toxascaris leonina, Ancylostoma tubaeforme, Echinococcus multilocularis, Dipylidium caninum, Taenia taeniaeformis, parasitizing cats. Emodepside, which is part of the drug, is a semi-synthetic compound from the group of depsipeptides and has a nematocidal effect. By exerting a stimulating effect on presynaptic latrophilin receptors, emodepside causes paralysis and death of the parasite. The mechanism of action of praziquantel is the depolarization of neuromuscular ganglion blockers, disruption of glucose transport and microturbular function of all phases of cestode development, causing disruption of neuromuscular innervation, paralysis and death of parasites. The pharmacokinetic properties of the drug ensure its good absorption from the site of application and long-term preservation in therapeutic concentrations in the animal’s body. Maximum concentrations of praziquantel and emodepside are observed in the blood serum after 2–4 days; Compounds are excreted from the body mainly in urine in unchanged form and partially in metabolized form within 28–30 days. In terms of the degree of impact on the body, Profender is classified as a moderately dangerous substance; in recommended doses it does not have a locally irritating, embryotoxic, teratogenic, mutagenic or immunotoxic effect. The drug is well tolerated by cats of different breeds in a therapeutic dose and in a 3-fold therapeutic dose.

Side effects

As a rule, there are no side effects and complications in cats of pure and mixed breeds, including pregnant and lactating cats, when using the drug in accordance with these instructions. In rare cases, after using the drug, individual reactions are possible (redness of the skin, itching, increased salivation), which resolve spontaneously and do not require the use of medications.

Contraindications

Profender should not be used on kittens under 8 weeks of age.

special instructions

During the procedure with a professional, you should follow the generally accepted rules of personal hygiene and safety precautions provided for when working with medicinal products for animals. At the end of the procedure, you should wash your hands thoroughly with warm water and soap. Do not wash, pet or allow the animal near small children for 24 hours after treatment with the drug. If you accidentally get the drug on your skin or eyes, rinse it off immediately with a stream of water; if it gets inside, consult a doctor. Empty drug pipettes must not be used for household purposes; they are placed in a plastic bag and thrown into a trash container.

Storage conditions

In a dry, dark place, out of reach of children, at a temperature of 0 to 30 °C.

Manufacturer

Bayer, Germany.

Contraindications for use and possible side effects

The drug "Profender" is approved for use in cats of all age groups. The instructions indicate that this product is prohibited from deworming kittens less than 8 weeks old and weighing less than 500 grams.

All other pets can use drops. Pregnant cats and females who are lactating (feeding kittens) are no exception. But it is worth considering that the animal may have individual intolerance to the component composition.

To exclude the development of side effects, it is necessary to carefully monitor the cat’s well-being for several days after applying Profender drops. The following may be side effects:

• intestinal disorder;
• lethargy, drowsiness;
• allergic response.

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To alleviate the condition and remove pathological symptoms, the cat must be bathed and given a sorbent to drink. If such reactions develop, you should stop treatment with Profender and not use it again.

Sometimes, while using the drug, side effects of the drug develop that do not pose a danger to the cat. This is copious salivation and redness of the skin. If such conditions develop, the medication should be discontinued and a veterinarian should be consulted.

Cost of the drug

Each package contains two pipettes with the drug. The amount of contents in them will fluctuate depending on the weight of the pet for which they are intended. That is why the price also fluctuates depending on the dosage in the range of 600-850 rubles. The lower price limit is drops for cats up to 2.5 kilograms, the upper limit is for cats 5-8 kg.

Along with such advantages as the effectiveness and convenience of treatment (it is much easier to bury the withers than to force-feed pills to an animal), there are also disadvantages of Profender. These include the high price of the drug and a strong unpleasant odor. However, using drops for the sake of the health of your pet “fluffy” covers all the inconveniences!

special instructions

Profender is considered a safe drug for cats, but you should talk to your veterinarian before using it, this is especially important if you have serious health problems. But even if the animal feels well, it is necessary to strictly follow the recommended dosage of the drug

In addition, you should adhere to some rules:

It is forbidden to buy a cat within 1-3 days after using the drops. In the first twenty-four hours after treatment, you should not pick up your pet or even just pet it. It is important to completely exclude contact between the animal and children - if the medicine gets on the child’s skin, allergic reactions are possible.

Before treating a cat with Profender, it should be shown to a veterinarian. He will determine the exact cause of the ailment and, if necessary, calculate the required dosage.

Animals of any age and breed are at risk of becoming infected with worms. A professional will help you get rid of uninvited guests and keep your cat healthy.

How to use Profender for cats correctly

It is prescribed for deworming animals for therapeutic and prophylactic purposes for nematodes and cestodiases. The medicine must be applied dropwise (topically).

First, you need to remove the protective cap from the pipette, position it vertically, and pierce the protective membrane of the pipette. The cat is picked up, its fur is parted at the withers, Profender is applied to the skin, squeezing the pipette. If the animal is large, then the contents of the pipette should be dripped in several places at the base of the skull. The minimum therapeutic dose is 0.14 ml per kilogram of animal weight.

The anthelmintic agent can be used in kittens from eight weeks of age, taking into account their weight. Therefore, it is produced in three types: for small cats (from 2.6 to 5 kg), for medium ones (from 5.1 to 8 kg), for large ones (more than 8 kg). After treatment, pets cannot be bathed for 24 hours, and it is also recommended to isolate them from contact with children.

Deworming of animals, according to the instructions, must be carried out for therapeutic purposes according to indications. With preventative care - every quarter.

There are no side effects or complications after using the drug in representatives of different breeds, including lactating and pregnant cats.

When working with Profender, you must follow the rules of hygiene and safety: do not smoke, do not drink, and wash your hands thoroughly with soap after finishing work.

Used pipettes must not be used for personal household needs - they must be disposed of.

Dosage

The minimum therapeutic dose is 0.14 ml. for every kilogram of the cat's weight.

You can start treating cats with Profender at two months of age.

For kittens and small cats weighing up to 2.5 kg, pipettes with a volume of 0.35 ml are used. For pets weighing up to 5 kg, a 0.7 ml pipette is sufficient. For deworming large animals weighing up to 8 kg, 1.2 ml pipettes are used. For cats weighing more than 8 kg, several pipettes of various volumes are combined, based on the minimum dose depending on the weight of the animal.

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For therapeutic purposes, according to indications, Profender should be given to a cat once. Every quarter it is recommended to carry out treatment for preventive purposes.

Profender is absorbed after 2 hours; during this time it is necessary to ensure that the animal does not lick the drops. Afterwards, if necessary, the cat can be washed.

In case of an overdose and the animal experiences tremors, vomiting or other signs of discomfort, the drug must be washed off the skin with water and detergent and rinsed with running water.

If necessary, take general measures to remove the drug from the body, use symptomatic and antihistamines.

If you use Profender correctly for deworming cats, and fully adhere to the instructions for use, then no side effects of the drug are observed. Skin reactions, itching or redness occur very rarely, but in most cases they resolve spontaneously without the use of medications.

It is not recommended to use these drops simultaneously with other anthelmintic drugs.

4 Instructions for use and storage conditions of the drug

Antihelminthic prophylaxis is carried out quarterly. Treatment for worms is carried out once as prescribed by a doctor. After contact with the skin, the medicine penetrates the body within two hours. The drug is excreted in the urine within 28-30 days.

It is necessary to observe safety precautions when working with Profender drops. Before starting the procedure, you must wash your hands using detergent.

After applying the drug, you need to discard the ampoule and wash your hands thoroughly. During deworming, animals are prohibited from eating, drinking, or smoking.

It is recommended to avoid direct contact with Profender to avoid an allergic reaction to its components. If the solution gets on the skin and mucous membranes of the nose, mouth or eyes, rinse the drug with plenty of warm water. If allergic reactions occur, you should contact the nearest medical facility for help.

Profender is stored at a temperature of +15 to +25°C, out of the reach of children. Shelf life: three years from the date of production. After the expiration date, the medicine should not be used.

Drops for cats, on the withers from helminths Bayer Profender, 0.5-2.5 kg

I. General information Trade name of the medicinal product: Profender®. International nonproprietary name: emodepside, praziquantel.

Dosage form: drops on the withers against worms in cats for external use (spot-on).

Profender 1 ml contains as active ingredients:

• emodepside - 21.43 mg
• praziquantel - 85.75 mg,

as well as excipients:

• butylhydroxyanisole - 5.4 mg,
• isopropylidene glycerol - 945.82 mg
• lactic acid - 21.6 mg.

In appearance, the drug is a transparent solution from yellow to light brown.

Profender is produced packaged in 0.35; 0.7; 1.12 ml in polypropylene pipettes of appropriate capacity with caps. Pipettes, 2 pieces each, are placed in a blister of aluminum foil and packaged in cardboard boxes along with instructions for use.

Store the drug in the manufacturer's sealed packaging, in a dry place, protected from direct sunlight, separately from food and feed, at a temperature from 0°C to 30°C. The shelf life of the drug, subject to storage conditions, is 3 years from the date of production. Profender should not be used after the expiration date.

Profender should be stored out of the reach of children.

Unused drug is disposed of in accordance with legal requirements.

II. Pharmacological properties of Profender Drops belong to combined drugs against worms (helminths). The active components included in the drug provide its wide spectrum of anthelmintic effect on round and tapeworms, including Toxocara cati (mature individuals, immature individuals, larval stages L3, migrating in the body and L4, parasitizing in the gastrointestinal tract), Toxascaris leonine (mature individuals, immature individuals, L4 larvae), Ancylostoma tubaeforme (mature individuals, immature individuals, L4 larvae), Echinococcus multilocularis, Dipylidium caninum, Taenia taeniaeformis, parasitic in cats.

Emodepside is a semi-synthetic compound from the group of depsipeptides and has pronounced nematocidal properties. By exerting a stimulating effect on presynaptic latrophilin receptors, emodepside causes paralysis and death of the parasite.

Praziquantel is a compound of the pyrazinisoquinoline group, active against gastrointestinal cestodes at all phases of development. The mechanism of action of praziquantel is the depolarization of neuromuscular ganglion blockers, disruption of glucose transport and microtubular function of cestodes, causing disruption of muscle innervation, paralysis and death of parasites.

The pharmacokinetic properties of the drug ensure its good absorption from the site of application and long-term preservation in therapeutic concentrations in the animal’s body. Maximum concentrations of praziquantel and emodepside are observed in the blood serum after 2-4 days. The compounds are excreted from the body within 28-30 days: emodepside - unchanged, mainly with feces; praziquantel - mainly in the urine.

In terms of the degree of impact on the body, Profender is a moderately hazardous substance (hazard class 3 according to GOST 12.1.007-76), in recommended doses it does not have a locally irritating, embryotoxic, teratogenic, mutagenic or immunotoxic effect; well tolerated by cats of different breeds and ages. The drug is toxic to fish and other aquatic organisms.

III. Directions for use Profender is prescribed for deworming (destruction of worms) of cats for prophylactic and therapeutic purposes against nematodes (toxocariasis, toxascariasis, hookworm disease) and cestodiasis (tenidosis, dipylidiasis, echinococcosis).

A contraindication to the use of Profender is the increased individual sensitivity of the animal to the components of the drug. Profender should not be used on kittens younger than 8 weeks of age and/or weighing less than 0.5 kg. The drug should not be applied to wet or damaged skin.

Profender drops are used externally, by topical (spot-on) application to the skin. Before use, remove the protective cap from the pipette and, positioning it vertically, pierce the protective membrane of the pipette nose (putting the cap on the back side), then remove the cap again. The drug, by spreading the fur, is applied to places inaccessible for licking, directly on the skin between the shoulder blades at the base of the neck.

When treating large cats, the contents of the pipettes are applied to the skin in the neck area in several places that are inaccessible to the animals for licking. The minimum therapeutic dose of Profender is 0.14 ml/kg of animal weight.

Deworming of cats using the drug Profender is carried out starting from 8 weeks of age, in the doses indicated in the table:

When treating cats weighing more than 8 kg, Profender is used at the rate of 0.14 ml per kg of animal weight, using combinations of pipettes of various packaging.

Treatment of cats for worms for therapeutic purposes is carried out according to indications, once; for preventive purposes - quarterly.

The time required for absorption of the drug is about 2 hours. After this time, the animal can be washed, if necessary.

In case of an overdose of the drug, some cats may experience: increased salivation, vomiting, and tremor. In this case, the drug is washed off with water and detergent and general measures are used to remove it from the body.

No specific effects of the drug upon first use or discontinuation have been identified.

When processing animals, you should adhere to the interval recommended by the instructions. If the next treatment is missed, the use of the drug is resumed at the same dose according to the same regimen.

As a rule, there are no side effects or complications when using Profender in accordance with these instructions. In rare cases, individual skin reactions (redness, itching) are possible, which resolve spontaneously and do not require the use of medications. If allergic reactions occur in an animal sensitive to the components of the drug, the drug should be thoroughly washed off with soap and water and the fur should be rinsed with plenty of running water, and, if necessary, antihistamines and symptomatic agents should be prescribed.

Profender should not be used simultaneously with other anthelmintic drugs.

The drug Profender is not intended for use in productive animals.

IV. Personal preventive measures When working with the drug Profender, you should follow the generally accepted rules of personal hygiene and safety precautions provided for working with medicines. Smoking, drinking and eating are not allowed during work. When finished, wash your hands thoroughly with warm water and soap. The animal should not be petted or allowed near small children for 24 hours after treatment.

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. People with hypersensitivity to the components of the drug should avoid direct contact with Profender. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label).

Empty medicinal product packaging must not be used for household purposes; it must be disposed of with household waste.

Organization-; Manufacturing address: KVP Pharma Veterinar Produkte GmbH; Projensdorfer Str. 324, D-24106 Kiel (Germany).

Mechanism of action

The medicine is a broad-spectrum drug against worms. This is ensured thanks to the main components of the drug, emodepside and praziquantel. They affect tapeworms and roundworms at all stages of their development (larva - immature individual - mature parasite). The components block the muscle activity of the parasite. It cannot attach to the intestinal walls and dies from starvation. Taking laxatives after using Profender is not required.

The main active ingredients work in one direction - the destruction of helminths. Description and properties:

1. Emodepside is a semisynthetic depsipeptide with pronounced nematocidal properties. The drug stimulates certain groups of receptors, leading to paralysis and death of parasites.
2. Praziquantel is a substance from the pyrazinisoquinoline group, effective against gastrointestinal cestodes at all stages of development. Praziquantel depolarizes neuromuscular parasite blockers, interfering with glucose transport. The process disrupts muscle innervation, which leads to paralysis and subsequent death of helminths.

Good absorption of the drug is due to its pharmacokinetic properties. The substance remains in the pet’s body for a long time. In blood serum, the main active components reach their maximum concentration after 2-4 days. Profender does not have a toxic effect on the liver and kidneys. The compounds are excreted after a month in urine and feces.

Properties of the drug and its effect

Profender is a combined broad-spectrum anthelmintic drug for deworming cats. The active components of the drops have a detrimental effect on tapeworms, as well as roundworms at various stages of their development.

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The active ingredients of the drug include: emodepside and praziquantel, and the auxiliary ingredients: butylhydroxyanisole, isopropylidene glycerol and lactic acid. Emodepside and praziquantel, as a result of different mechanisms of action, cause paralysis in parasites, leading to their death.

When applied, Profender is well absorbed and remains in the cat’s body for a long period in a therapeutically required amount. Achieving the maximum concentration of the active substances of the drug in the animal’s blood serum is expected on days 2-4. The drug is excreted from the animal’s body naturally through urine and feces in about a month.

Profender is well tolerated by cats of all breeds and age groups. It is considered a moderately hazardous substance. When used in adequate doses, it does not cause local irritation or any other negative reactions of the body.

Composition and description

Dirofen contains 2 active ingredients - febantel and pyrantel, excipients: calcium stearate, praziquantel, talc, lactose, aerosil, carboxylmethylcellulose. The mechanism of action of the drug is the paralysis of parasites due to neuromuscular blockade under the influence of pyrantel and the destruction of cells of the digestive system of helminths due to the action of febandel. The action of two active substances leads to the death of parasites and their removal naturally from the body.

The drug is available in the form of tablets Dirofen and Dirofen Plus. The first are intended for kittens and puppies, Dirofen Plus - tablets for adult cats and dogs. Medicines are produced in the form of tablets, 6 pieces per blister.

Indications for use of Profender

Drops for helminths are prescribed for pets with tapeworms and roundworms - nematodosis and cestodosis (for therapeutic purposes). The drug is also prescribed in order to avoid these diseases.

Use for the treatment of mixed parasitic infestations in cats:

Adults, mature individuals and larval species of nematodes

Toxocaracati, Toxascarisleonina, Ancilostomatubaeforme;

Cestodes

Dipylidiumcaninum, Taeniataeniaformis, Echinococcus multilocularis.

Prevention and treatment of round and tape parasites at any stage of their formation:

1. Hookworm;
2. Toxocariasis;
3. Toxascariasis;
4. Dipylidiasis;
5. Tenidoses;
6. Echinococcosis.

Description, composition and release form

“Profender” is the trade name of the anthelmintic drug. International name: emodepside, praziquantel. The potent components included in the composition kill various parasites: round and tapeworms, cestodes and nematodes.

"Profender" is produced by the German concern "Bauer". Release form: anti-worm drops for cats. Compound:

• emodepside - 21.43 mg;
• praziquantel - 85.75 mg;
• butylhydroxyanisole - 5.4 mg;
• isopropylidene glycerol - 945.82 mg;
• lactic acid - 21.6 mg.

The content is indicated in 1 ml of the drug.

Anthelmintic for cats up to 2.5 kg Bayer Profender, Drops on the withers, treatment and prevention of worms

Profender®

– a combined anthelmintic drug. 1 ml of the drug contains emodepside - 21.43 mg and praziquantel - 85.75 mg. Profender® is available in the form of drops on the withers in three dosages - for kittens and cats up to 2.5 kg, for cats 2.5–5 kg and for cats 5–8 kg. (Bayer, Germany).

Indications

Profender is prescribed for deworming cats for preventive and therapeutic purposes against nematodes (Toxocara sati, Toxascaris leonine, Ancylostoma tubaeforme) and cestodias (Echinococcus multilocularis, Dipylidium caninum, Taenia taeniaeformis).

Application

The drug is used externally, applied to places inaccessible for licking, directly onto the skin between the shoulder blades at the base of the neck. The drug is applied to dry, intact skin. Profender® can be used on kittens over 8 weeks of age and/or weighing more than 0.5 kg. The time required for absorption of the drug is about 2 hours. After this time, the animal can be washed if necessary.

Dosing by weight

Mechanism of action

The mechanism of action of praziquantel is the depolarization of neuromuscular ganglion blockers, disruption of glucose transport and microtubular function of cestodes; praziquantel causes disruption of muscle innervation, paralysis and death of parasites. By exerting a stimulating effect on presynaptic latrophilin receptors, emodepside causes paralysis and death of the parasite.

Efficiency

Deworming of cats with Profender is carried out once. The active components included in the drug provide a wide range of anthelmintic effects on round and tapeworms, and also act on different stages of the life cycle of helminths - mature individuals, immature individuals, larval stages L3, migrating in the body, and L4, parasitizing in the gastrointestinal tract .

Safety

As a rule, there are no side effects or complications when using the drug in accordance with these instructions. The shelf life of the drug, subject to storage conditions, is 3 years from the date of production.

Indications for use

For the treatment and prevention of mixed helminthic infestations, as well as nematodes and cestodes, Profender drops for cats are most effective. The instructions note that the drug begins to act only after 2 hours, and the highest concentration of active substances in the animal’s blood is observed after 2-4 days. This effect lasts for almost a month. Therefore, drops are applied once for therapeutic purposes.

But it is recommended to regularly deworm the animal for preventive purposes.

This is especially important for those cats that go outside for walks. Therefore, prophylactic application of the drug "Profender" is recommended every 2-3 months

This way the pet will be protected from infection.