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Liver disease can overtake your cat suddenly, bringing great discomfort to the animal and the owner. However, modern medicine is directing all its efforts to cure such serious diseases as cirrhosis and fibrosis of the liver, as well as various forms of hepatitis. For this, veterinarians often prescribe Essentiale for cats. How to use this medicine and how to give it to your pet? Details in this article.
Brief characteristics of the drug
- Drug name: Essentiale N
- Name in Latin: Essentiale N
- Active ingredient: soy essential phospholipids
- Pharmacological group: hepatoprotector, cytoprotector
- Object of application: humans, dogs, cats and other mammals
- Where to buy: medical pharmacies
- Release form: solution for intravenous injection in ampoules of 5 ml (250.00 mg of 3-sn-phosphatidyl choline), capsules of 300 mg
- Physical properties: yellow solution, transparent, easily foams; bright yellow, almost brown powder
Feedback from cat owners
Most of the reviews from cat owners who use Essential are positive. Ease of use and quick results are noted.
Nikolai. We struggled with unpleasant odors in the house for a long time until we realized that they were mainly emitted by our already middle-aged Persian cat. We started using Essential on the advice of a veterinarian, because the shampoos only had an effect for 3-4 weeks. As a result, not only the smell itself disappeared, but also the fur became shiny and glossy - just like that of a young cat. One course was enough - they applied it once a week for 2 months in a row.
Antonina. There were never any special problems with our cat, but then we had to travel - first by car, then on an airplane. Naturally, this is an inconvenience. But before I would never have thought that fur could give off a weak, specific smell. Therefore, I had to use the Essential product.
Cat owners speak positively about the drug Essential.
Veronica. My cat has long-standing problems with dandruff and dry skin - as the veterinarian said, hormonal changes due to age (she is already 7 years old). Of course, we tried ointments and lotions. They had an effect, but after some time the old story repeated itself. I advise everyone not to self-medicate, but to contact a veterinarian.
Release form
are available :
- Injection form. Solution for intravenous injection in ampoules of 5 ml. Contains the active substance: essential phospholipids, which are phosphatidylcholine isolated from soybeans, a dried extract that consists of 93% 3-sn-phosphatidylcholine in a dose of 250 mg. There are also excipients: deoxycholic acid - 126.5 mg; sodium chloride - 12 mg; benzyl alcohol - 45 mg; riboflavin - 0.5 mg; sodium hydroxide - 13.4 mg; water - up to 5 ml.
- Capsules containing as an active ingredient: essential phospholipids, which are phosphatidylcholine isolated from soybeans, which contains 76% 3-sn-phosphatidylcholine in a dose of 300 mg. Excipients: soybean oil - 36.0 mg; solid fat - 57 mg; castor oil - 1.6 mg; ethyl vanillin - 1.5 mg; ethyl alcohol 96% - 8.1 mg; alpha tocopherol - 0.75 mg; 4-methoxyacetophenone - 0.8 mg. The capsule contains: gelatin - 67.945 mg; titanium dioxide - 0.83 mg; water - 11.495 mg; iron oxide black (dye) - 0.332 mg; iron oxide yellow (dye) - 2.075 mg; sodium lauryl sulfate - 0.125 mg; iron oxide red (dye) - 0.198 mg.
Side effects
If the prescribed dosage and treatment regimen are followed, the risk of negative effects is minimal. The following side effects may occur when taking the drug:
- Increased salivation that occurs a few minutes after taking the medicine. This condition is not dangerous and goes away on its own.
- The appearance of hypersensitivity reactions. In this case, therapy should be stopped and antihistamines are recommended.
- If vomiting occurs while using Hepatovet for cats, you should consult your doctor. It may be necessary to adjust the dose, change therapy, or take additional medications.
Symptoms of drug overdose in cats have not been established.
Pharmacology Essentiale N
Pharmacological effects – hepatoprotective, cytoprotective.
Pharmacodynamics of the drug Essentiale N
Essential phospholipids
represent the main structural elements of the cell wall and membranes of intracellular organelles. In liver pathology, damage to the cell membranes of hepatocytes and their organelles always occurs. This phenomenon is called hepatocyte cytolysis syndrome, which is biochemically manifested by an increase in the activity of alanine and aspartic transaminases in the blood serum. This syndrome causes disruption of the activity of enzymes and receptors, leading to a deterioration in the structural and functional state of hepatocytes. Their ability to regenerate is also reduced.
Phospholipids included in
, are completely consistent in their physicochemical structure with endogenous phospholipids. The activity of essential phospholipids is significantly higher, which can be explained by their higher content of polyunsaturated fatty acids. The above-mentioned high-energy molecules are integrated into defective areas of the membranes of the cell wall of liver cells, which helps restore the integrity of hepatocytes and stimulates their regeneration. The cis-double bonds of the polyunsaturated fatty acids that make up the composition neutralize the parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes, while the structure of the phospholipids of the liver cell membranes “looses,” which leads to an increase in their elasticity and fluidity. Thanks to this, metabolism in hepatocytes significantly improves.
Essential phospholipids, which are the active ingredient of Essentiale, in the body of humans, dogs and cats have a regulating effect on the metabolism of lipoproteins by transporting cholesterol and neutral fats to the sites of their oxidation. This pharmacological effect of essential phospholipids is associated with an increase in the ability of high-density lipoproteins to conjugate with cholesterol.
The cardioprotective properties of Essentiale have been described in humans, dogs and cats.
The drug has a normalizing effect on:
- on detoxification, urea-synthesizing, protein-synthesizing functions of the liver
- on the preservation and restoration of phospholipid-dependent enzyme systems and the cell wall of hepatocytes, which inhibits the formation and proliferation of fibrous connective tissue in the liver
- metabolism of proteins and lipids
- due to the release of phospholipids into the bile, the lithogenic index is significantly reduced, which leads to the stabilization of bile and the prevention of cholelithiasis
Pharmacokinetics of Essentiale
In the body of humans, dogs and cats, phosphatidylcholine enters hepatocytes, and it is conjugated with high-density lipoproteins.
The half-life of the choline component is about 66 hours, and the polyunsaturated fatty acids are about 32 hours.
Pharmacological properties
The beneficial effect of the hepatoprotector Hepatovet on the liver is due to its complex composition.
The biologically active components of the drug have the following pharmacological properties:
- Thanks to the action of phospholipids, hepatocyte membranes are restored and protected, metabolic processes are improved, water and fat metabolism are stabilized, enzyme activity increases, and the development of fibrosis stops.
- Normalization of protein production. As a result, the glycogen supply in the liver increases, contributing to the body’s resistance to the effects of toxic substances, and chemical reactions are accelerated.
- Hepatovet is effective for the prevention and treatment of fatty liver degeneration (lipidosis), due to the methionine content in the drug, which prevents the increase and accumulation of lipids in the organ. The amino acid also increases the activity of hormones, vitamins, and proteins. Increases the concentration of phospholipids.
- Detoxifying properties, accelerating the removal of toxins.
- General strengthening effect on the digestive gland.
- Elimination of stagnation in the biliary tract, increasing bile secretion while reducing its viscosity, improving its outflow.
- Due to the content of L-ornithine in the preparation, its regenerating effect is noted, as well as the ability to remove ammonia from the body.
- Anti-inflammatory and analgesic qualities of the drug.
Indications for use of the drug Essentiale N
According to the instructions for use of the drug Essentiale in humans, dogs and cats, the following indications are established:
- liver cirrhosis, acute and chronic hepatitis, hepatocyte necrosis, hepatic precoma and coma, toxic or drug-induced hepatitis
- cardiohepatic syndrome (cardiac liver fibrosis, congestive liver)
- hepatocardial syndrome (myocardial dysfunction due to primary hepatic pathology)
- fatty liver (particularly in diabetes mellitus)
- toxicosis of pregnancy
- hepatocyte cytolysis syndrome
- post- and preoperative therapy, in particular during operations in the area of the liver, gallbladder and ducts
- radiation syndrome
- psoriasis
When is it prescribed?
For cats and female cats, Essentiale is indicated for use in the presence of the following pathological conditions:
- exacerbation and chronic forms of hepatitis;
- cirrhosis of the liver;
- impaired functioning of the largest digestive gland;
- death of liver parenchyma cells;
- diabetes mellitus with liver organ dystrophy;
- toxicosis;
- psoriasis;
- the period after surgery.
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Method of using essentiale in humane medicine and its dose to humans
The drug is used in the form of intravenous injections. It is undesirable to inject this drug intramuscularly, which is due to the development of local reactogenic reactions (the drug irritates soft tissues and causes an inflammatory reaction). The standard dose of Essentiale for humans is 5–10 ml (1–2 ampoules). For severe forms of hepatopathy, use 10–20 ml (2–4 ampoules) per day. The contents of 2 ampoules (10 ml) can be administered intravenously at a time. The drug can be used twice a day. It is strictly forbidden to mix essential phospholipids in the same syringe with other medications. It is recommended to dilute the drug with the patient’s blood in a 1:1 ratio (using autologous blood).
If necessary, the drug is diluted with only a 5-10% glucose solution, and the diluted drug solution should be transparent throughout the entire time of intravenous injection.
It is strictly forbidden to dissolve the drug with electrolyte solutions (isotonic nitride chloride solution, Ringer's solution, etc.).
It is recommended to supplement intravenous administration with oral forms of the drug as quickly as possible.
The drug is also used orally. Capsules of the drug must be swallowed whole and washed down with a sufficient volume of water (about 200 ml).
For adults and adolescents over 12 years of age, take 2 capsules 3 times a day with meals. The duration of use of Essentiale is not limited (determined by the attending physician).
Directions for use
Hepatovet suspension is intended for oral use. It can be stored for 2 years at a temperature of 2 to 25 degrees, after opening - no more than 3 weeks.
When treating with the drug, the following rules of administration are established:
- Shake the suspension thoroughly for 1-2 minutes before use.
- The drug is taken orally by combining it with a small volume of food or using a dispenser syringe included with the drug. It is preferable to squeeze the product onto the root of the animal’s tongue or into the cheek area, this speeds up swallowing and reduces taste sensitivity.
- The frequency of use per day is 2-3 times.
- If you miss a medication, you do not need to double the dose; you should take it in the prescribed dosage according to the standard regimen.
- Duration of therapy is 3-5 weeks. Repeat treatment - after 2-3 weeks.
- The dosage of Hepatovet is determined individually, based on the weight of the cat. With a large mass, the frequency of administration can be increased.
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| Animal weight, kilogram | Single dosage, milliliters | Permissible dosage per day, milliliters |
| until 3 | 1 | No more than 3 |
| 3-6 | 2 | No more than 6 |
| From 7 or more | 3 | No more than 9 |
When answering the question, is it possible Hepatovet for kittens, the answer is positive, provided that the dose is observed (no more than 2-3 milliliters per day). The drug is also approved for use by pregnant cats, as it does not have a teratogenic effect on the fetus. It is compatible with feed and additives, and other medications.
Method of application of essential veterinary medicine and its dose for dogs and cats
The drug is used in cats and dogs as intravenous injections. This drug is not injected intramuscularly (the development of local reactogenic reactions is possible). The standard dose of Essentiale for dogs and cats is 0.2-0.5 ml/kg body weight 1 time per day for 5-10 days. For severe forms of hepatopathy in dogs and cats, the drug is used intravenously 2 times a day for 2-3 weeks. The drug is diluted with autologous blood or dextrose solution. Saline solutions are not used to dilute Essentiale.
When using Essentiale for dogs and cats
It is recommended to replace or supplement the injection form of the drug with an oral one as soon as possible.
The drug is also used orally. Cats and cardic dogs use 1/4 capsule of Essentiale, medium breeds - 1/2 - 1 capsule, large and giant breeds - 1-2 capsules of 2-3 rvd for 2-4 weeks.
Who will it harm?
The drug "Essentiale" is a low-toxic drug that is highly effective and excellent tolerability. But according to numerous studies that studied the effects of soy phospholipids on the body of cats, Essentiale should not be used by pets with personal intolerance to any component of its composition. It will not be beneficial, but will only harm the medicine if given to pregnant females, since the structure includes benzyl alcohol.
Contraindications to the use of Essentiale
According to the instructions for use of the drug "Essentiale", a number of contraindications have been established:
- allergic reactions
- children under three years of age
- allergy and hypersensitivity to any of the ingredients of the drug
Use Essentiale with caution during pregnancy
, since the drug contains benzyl alcohol, which penetrates the hematoplacental barrier quite well. Clinical studies have established that the use of drugs containing benzyl alcohol in newborns with a high frequency of developing dyspnea syndrome with a fatal outcome.
Side effects on the drug Essentiale
In humans, dogs and cats, side effects on Essential are extremely rare.
The following side effects are described:
- allergies (urticaria)
- delayed type hypersensitivity
- diarrhea
- nausea
- bitter taste in the mouth
- itching
- skin rash
- a soft chair
- stomach discomfort
special instructions
Only use a clear solution. Foaming may occur when using the drug.
Release form
Ampoules with a solution for intravenous injection, 5 ml each, containing 250 mg of essential phospholipids. Ampoules of 5 ml (dark glass).
Capsules that contain 300 mg of active substance.
Manufacturer
FamarHealthCareServices (Madrid, Spain). Address: Avenida de Leganes, Alcocorn (Madrid), Spain.
Storage conditions for the drug "Essentiale N"
Store out of the reach of children, namely in the refrigerator at a temperature of 2 to 8 °C.
Expiration date of the medicine
According to the instructions for use for humans, dogs and cats, the shelf life is three years.
The drug should not be used after its expiration date.
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Side effects
As a rule, there are no side effects when using Essentiale Forte in cats. However, in some cases, the following symptoms may appear:
- Diarrhea.
- Nausea and vomiting.
- Bitterness in the mouth (the cat drinks a lot of water and often sticks out its tongue).
- Itching.
- Flatulence or any other stomach discomfort.
At the first sign of these symptoms, you should contact a veterinarian, since it is possible that a slight intoxication occurs in the cat’s body with substances of the drug, the dosage of which turned out to be more than required.
Thus, a cat should be given Essentiale only after consultation with a specialist and a correct diagnosis. “Essentiale” copes well with many liver diseases, and also successfully defeats hepatitis and gallbladder dysfunction, helping to remove all harmful substances from your pet’s body.
