Api-San Amoxisan broad-spectrum antibacterial drug for cats and dogs (Code: 41519)

About the drug: pharmacology, composition, release form

Amoxisan for injection is available in the form of a sterile suspension. It is based on amoxicillin trihydrate, an antibiotic of the penicillin group. In terms of 1 ml of solution – 150 mg of active substance.

The mechanism of action of amoxicillin is aimed at inhibiting the activity of bacterial enzymes, in particular trans peptidases.

On sale it is found in dosages from 10 to 250 ml. The factory packaging includes a dark glass bottle, standardly closed with a rubber cap and sealed on top with an aluminum cap. Each package is supplied with instructions for use. Possible packaging options: cardboard boxes or shipping containers.

Amoxisan for cats: application

The drug is suitable for the treatment of all mammals with infectious, primary and secondary diseases caused by bacteria sensitive to penicillin antibiotics:

• Atrophic rhinitis;
• Respiratory system infections;
• Infectious diseases of the digestive system;
• Diseases of the joints of bacterial etiology;
• Infectious diseases of the genitourinary system;
• Infectious lesions of the skin and soft tissues;
• Necrobacteriosis.

Amoxisan belongs to the group of semi-synthetic antibiotics, is universal in the degree of impact, and belongs to the third hazard class according to GOST requirements.

Contraindications and side effects

Instructions for use contain detailed information on contraindications for Amoxisan. Its use is not recommended:

• for newborn kittens;
• if the cat is individually intolerant to all drugs of the penicillin group;
• if there are functional problems of the kidneys and liver.

For pregnant and lactating cats, its use is possible only under the supervision of a specialist.

According to reviews, the drug is generally well tolerated by cats, but Amoxisan should not be combined with other antibiotics, namely fluoroquinolones, cephalosporins and penicillins. In addition, concomitant therapy with chloramphenicol and thiamphenicol should be avoided. The instructions for use specifically state that one syringe should contain only Amoxisan and nothing else.

Monitor dosage carefully. If it is exceeded, the cat begins to vomit, refuses to eat and loses coordination of movements.

Among the side effects, the instructions for use warn of the risk of swelling, which goes away without any action within up to 2 days. According to reviews, there are few such cases.

Are there any analogues?

The drug Amoxoil is prescribed for the same problems in an animal, but it lasts much longer.
If it is necessary to replace Amoxisan, pharmaceuticals with similar effects are prescribed. Veterinarians often prescribe Amoxoil for cats. It has a prolonged effect and helps pets get rid of viral and bacterial diseases. Amoksoil eliminates inflammatory processes in the genitourinary system, cures rhinotracheitis, bronchitis, atrophic rhinitis and various primary and secondary infections in purring cats. Typically, the dosage of this AB is 1 ml per 10 kilograms of animal weight. If necessary, the medicine is re-administered, but not earlier than a 2-day break.

But there are also other analogues, including:

• "Amoximag";
• "Amoxicillin";
• "Clamoxil";
• "Amoxilong";
• "Vetrimoxin".

Storage conditions

Amoxisan must be stored in accordance with the requirements specified in the instructions for use:

1. Temperature parameters: +5…+25 °С.
2. Away from food.
3. In a place where animals and children cannot reach.

If the bottle has not been opened, then the antibiotic is suitable for use for up to 2 years. Once opened, it can be stored for approximately 28 days. According to reviews, it is better to do this in the refrigerator. It is advisable to maintain sterility: draw up the suspension with a new syringe each time. During storage, delamination is possible.

Amoxisan Dose for Dogs and Other Animal Species

• 500 kg - 50 ml, subcutaneously or intramuscularly, if necessary, repeat the injection after 48 hours
• 50 kg - 5.0 ml
• 5 kg - 0.5 ml
• 400 kg - 40 ml
• 40 kg - 4.0 ml
• 300 kg - 30 ml
• 30 kg - 3.0 ml
• 200 kg - 20.0 ml
• 20 kg - 2.0 ml
• 15 kg - 1.5 ml
• 100 kg - 10.0 ml
• 10 kg - 1 ml
• 1 kg - 0.1 ml, subcutaneously or intramuscularly, if necessary, repeat the injection after 48 hours

Animals should not be injected with more than 20 ml of the drug in one place.

The drug is sensitive to destruction by penicillinase; it is not effective against bacteria that produce penicillinase, especially resistant strains of staphylococci. All strains of Pseudomonas and most strains of Klebsiella and Enterobacter are resistant to amoxisan.

Feedback from cat owners

The cat has cystitis. Repeats exactly once a year. The last time the clinic prescribed Amoxisan injection. Previously, I bought more expensive analogues, but this time I was pleasantly pleased with the antibiotic of our production. I read the reviews - there are no complaints about the quality. The price was a little cheaper. It worked quickly too. After the second injection, all problems went away. Alena, 25 years old

A bacterial infection was suspected in the cat. She became lethargic and apathetic. The veterinarian prescribed Amoxisan. Injected 0.5 ml, intramuscularly, twice with an interval of two days. The only problem we encountered was mild dysbacteriosis. According to reviews, this often happens, so it makes sense to immediately buy something to restore the microflora. Inna, 20 years old

They took the cat to the dacha and didn’t notice: he probably ate something. Diarrhea, vomiting. The reason was never found, the veterinarian immediately prescribed Amoxisan along with vitamins and Smecta. We never had injections, but we did it surprisingly well. The cat bravely endured the treatment and after a week they forgot that there were health problems. Lisa, 28 years old

general information

The drug is sold in the form of a suspension for injection, which is bottled in 10, 50 or 250 ml bottles. Amoxisan contains the active component - amoxicillin trihydrate, as well as such auxiliary components as:

• highly dispersed synthetic silicon dioxide;
• methylparaben;
• stabilizer E494;
• preservative E216.

The principle of operation of the drug is to suppress the activity of pathogenic transpeptidase enzymes, which are involved in binding the main component of the cell wall of microorganisms - peptidglycan. “Amoxisan” is rightfully considered an antibacterial drug that has a pronounced bactericidal effect, which is aimed at reducing the ability of pathogenic bacteria to develop and multiply, as a result of which it dies. After injection, the maximum content of the active substance is observed after 3-4 hours, and the therapeutic effect continues for 48 hours. Amoxisan leaves the cat's body unchanged along with urine and bile. In terms of danger, the antibiotic is classified as moderately dangerous.

Adverse reactions

The use of the drug may cause negative reactions, such as loss of appetite and vomiting.
If the therapeutic dose is strictly followed, adverse reactions are unlikely. If the dosage is exceeded, there is no intoxication. In some situations, cats may experience an allergic reaction after using Amosin. It can be eliminated with the help of adrenaline, corticosteroids and other antihistamines. Sometimes, with an overdose, symptoms such as:

• oppression;
• dysfunction of the gastrointestinal tract;
• swelling at the injection site;
• poor appetite;
• vomit;
• impaired coordination of movements.

INDICATIONS AND USE OF AMOXISAN IN VETERINARY:

Dogs and other animal species: the drug is indicated for the treatment of the following infections caused by susceptible strains of microorganisms causing:

• Respiratory tract infections (tonsillitis, tracheobronchitis) caused by Staphylococcus aureus, Streptococcus spp., E.coli and Proteus mirabilis.
• Urinary tract infections (cystitis) caused by Staphylococcus aureus, Streptococcus spp., Escherichia coli and Proteus mirabilis.
• Gastrointestinal tract infections (bacterial gastroenteritis) caused by Staphylococcus aureus, Streptococcus spp., E.coli and Proteus mirabilis.
• Bacterial dermatitis caused by Staphylococcus aureus, Streptococcus spp. and Proteus mirabilis.
• Soft tissue infections (abscesses, lacerations) infected with Staphylococcus aureus, Streptococcus spp., E.coli and Proteus mirabilis.

Side effects

As a rule, the drug is well tolerated by cats, but sometimes the following may occur:

• allergic manifestations (fever, rhinitis, hyperemia of visible mucous membranes, itching of the skin);
• mild agitation or depression;
• convulsive reactions;
• vomiting and retching, excessive salivation;
• diarrhea;
• distortion of taste and refusal of usual food.

The most common of these are allergic reactions. Since the drug is administered once, special attention is not paid to allergies when prescribing.

The place where the injection was given may react with swelling, which resolves within 1-2 days after injection.

Amoxisan

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Name AMOXISAN Name (lat.) Amoxisan Composition and release form Antibacterial drug Amoxisan (International nonproprietary name: amoxicillin trihydrate) contains in 1 ml as an active substance 150 mg of amoxicillin in the form of trihydrate and auxiliary components: butylated hydroxytoluene, magnesium stearate, benzyl alcohol and vegetable oil. The drug is produced in the form of a sterile opaque suspension for injection from white to light yellow in glass bottles of 10 and 100 ml, packed in a cardboard box. Pharmacological properties The active antimicrobial component of the drug is chemically a semi-synthetic antibiotic from the penicillin group and has a wide spectrum of activity against both gram-positive and gram-negative microorganisms, including strains: Staphylococcus spp., Streptococcus spp., Actinomyces spp., Meningococcus spp., Escherichia spp., Shigella spp., Salmonella spp., Pasteurella spp., Listeria monocytogenes, Clostridium spp., Haemophilus spp., Bacillus spp., Actinobacillus spp., Bordetella spp., Fusobacterium spp., Moraxella spp., Corynebacterium spp. , Campylobacter spp., Erysipelothrix rhusiopathiae, Proteus mirabilis. Amoxicillin trihydrate does not act on penicillinase-forming bacteria Klebsiella spp, Enterobacter spp. and Pseudomonas spp. Amoxicillin trihydrate inhibits the biosynthesis of the cell wall of microorganisms, which leads to its death. After intramuscular administration of Amoxisan, the maximum concentration of amoxicillin trihydrate in the blood serum is achieved within 1 to 2 hours and is maintained at a therapeutic level for 48 hours. Amoxicillin trihydrate is excreted from the body mainly in urine and partially in bile, mainly in unchanged form. In terms of the degree of impact on the body of warm-blooded animals, Amoxisan is classified as a moderately hazardous substance. Indications Prescribed for therapeutic purposes in cattle, sheep, pigs, dogs and cats for infectious diseases of the gastrointestinal tract, respiratory tract, genitourinary system, joints, soft tissues and skin, including necrobacteriosis, umbilical sepsis, porcine atrophic rhinitis, mastitis syndrome metritis-agalactia and other primary and secondary infections of bacterial etiology, the pathogens of which are sensitive to penicillin antibiotics. Doses and method of administration Amoxisan is administered to animals subcutaneously or intramuscularly at a dose of 1 ml per 10 kg of body weight, which corresponds to 15 mg of active substance per 1 kg of body weight. If necessary, the drug can be re-administered after 48 hours. To administer amoxicillin trihydrate suspension, use only dry, sterile syringes and needles. If the administered dose of the drug exceeds 20 ml, it is recommended to administer it in several injections at different points. It is recommended to lightly massage the injection site after administering Amoxisan. Side effects In rare cases, with increased individual sensitivity and violation of the procedure for taking and dosing the drug, allergic reactions, refusal to feed, vomiting, and impaired coordination of movements are possible. In these cases, animals are prescribed desensitizing and symptomatic therapy. Swelling may develop at the injection site, which resolves spontaneously within 1 to 2 days and does not require the use of medications. Contraindications Increased individual sensitivity to amoxicillin and other penicillins. Do not administer intravenously. Amoxisan cannot be mixed with other drugs in the same syringe, and also cannot be used simultaneously with thiamphenicol, chloramphenicol, penicillin antibiotics, cephalosporins and fluoroquinolones. Special instructions Slaughter of animals for meat is permitted no earlier than 28 days after the last use of Amoxisan. The meat of animals forcedly killed before the expiration of the specified period can be used as feed for fur-bearing animals. Milk from dairy animals is allowed to be used for food purposes, no earlier than 96 hours after the last administration of the drug. Milk obtained earlier than the established period can be used after boiling as animal feed. Storage conditions: In a dry place, protected from light, out of reach of children and animals. Separated from food and feed in the manufacturer's packaging at a temperature of 5 to 20 °C. Shelf life: 2 years. Opened bottles of the drug can be stored for no more than 28 days. Manufacturer: Apicenna. Russia

Address: 143985, Moscow region, Balashikha district, Novomiletsky village, pos.
New Milet, Poltevskoe highway, Vlad. 4. Tel/fax More information about the manufacturer

All drugs are produced by Apicenna. Russia

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