Buy Medicine for dogs MERIAL Frontline COMBO S 2-10kg 1 pipette in Beethoven

Features of the drug

The manufacturer of the product is Pharmacological, France. This manufacturer has long been known to dog owners, because it produces a variety of drugs for animals that are highly effective.

Store the medicine at a temperature of 0 to 25 degrees. The storage place should be protected from moisture and sun. The shelf life is 3 years, before purchasing, check if this period has expired. After the expiration date, Frontline Combo cannot be used for dogs; this can cause a number of side effects, including death.

Frontline Combo, for cats, drops on the withers against fleas (eggs, larvae, mature forms) and ticks

INSTRUCTIONS for use Frontline Combo for cats COMPOSITION AND FORM OF RELEASE An insecto-acaricidal preparation in the form of a solution for external use, containing fipronil - 9.8% and S-methoprene - 8.8% as active ingredients, and polyvidone and polysorbate. It is a colorless transparent liquid with a weak specific odor. Available packaged in 0.5 ml polyethylene pipettes with a break-off tip. PHARMACOLOGICAL PROPERTIES It has a pronounced contact insecto-acaricidal effect, is active against the preimaginal and imaginal phases of development of lice, fleas, lice and ticks (ixodic, cheylitella), parasitic on cats. The mechanism of action of fipronil is to block GABA-dependent (GABA-gamma-aminobutyric acid) receptors of parasites, disrupting the transmission of nerve impulses, which leads to paralysis and death of ectoparasites. S-methoprene inhibits juvenile hormone, which promotes the formation of chitin, thereby disrupting the development of fleas at the egg and larval stages. When applied to the skin, the drug is not absorbed, but gradually, over 24 hours, distributed over the surface of the body and, reserved in the sebaceous glands, has a long-term insecticidal and acaricidal effect in places where ectoparasites are localized. In terms of the degree of impact on the body, Frontline Combo is a low-hazard substance (hazard class 4 according to GOST 12.1.007.76), in recommended doses, it does not have a skin-resorptive, sensitizing, embryotoxic, teratogenic or mutagenic effect. In case of contact with eyes, it causes mild irritation. INDICATIONS Prescribed to cats to combat fleas, lice, lice and ticks (ixodidae, cheylitella). DOSES AND METHOD OF APPLICATION Frontline Combo is used externally by topical (Spot On) application to the skin. Before treatment, break off the tip of the pipette, spread the animal’s fur in the back area (between the shoulder blades) and, pressing the pipette, apply the drug to the skin at one or several points. The protective effect of the drug against ixodid ticks in cats lasts up to 3 weeks, against the imago and preimaginal phases of insect development for up to 6 weeks. If the animal is severely affected by lice, fleas, or lice eaters, it is recommended to treat once a month. If the animal is washed more than 2 times a month, it is recommended to reduce the interval between treatments to 3 weeks. It is not recommended to wash animals within 48 hours after treatment with Frontline Combo, or to use other insecticidal and acaricidal agents. SIDE EFFECTS Allergic reactions are possible in hypersensitive animals. CONTRAINDICATIONS Increased individual sensitivity to the components of the drug. Sick and convalescent animals, as well as kittens under 8 weeks of age, cannot be treated. SPECIAL INSTRUCTIONS In case of increased individual sensitivity to the components of the drug and signs of allergic reactions appear, treatment is stopped, the drug is washed off with water, and antihistamines are given orally. During the procedure with Frontline Combo, you should follow the rules of personal hygiene and safety precautions provided for working with medicinal products for animals. While working with the medicine, you are not allowed to drink, smoke, or eat. If Frontline Combo accidentally gets on the skin or mucous membranes, it should be washed off with a stream of water. After finishing work, wash your hands with warm water and soap. Empty drug pipettes must not be used for household purposes; they must be disposed of with household waste. STORAGE CONDITIONS With precautions according to list B. In the manufacturer's packaging, in a dry place, protected from light and inaccessible to children and animals at a temperature of 0 to 25 ° C. Shelf life: 3 years. MANUFACTURER Merial S.A.S., France.

Composition and release form

The medicine is available in the form of a liquid for external use. The solution is transparent and has a slight unpleasant odor. It is packaged in plastic blisters and then, together with the pipettes, placed in cardboard boxes with a transparent title side. On the back of the package there are instructions for use and a short description of the product (action, composition, etc.).

One box can contain 1, 3 or 10 pipettes. The volume of the pipette depends on the weight of the pet: for the smallest - S (0.67 ml), for medium-sized dogs it would be appropriate to buy M (1.34 ml) or L (2.68 ml), and for owners of large breeds, XL (4.02 ml) is suitable.

The main active ingredients are fipronil and S-methoprene. The drug also contains additional components:

polyvidone;
diethylene glycol monoethyl ether;
polysorbate;
butylhydrotoluene;
butylated hydroxyanisole.

Drops for cats against parasites Frontline Combo, one pipette

An effective and high-quality drug, Frontline Combo, in a convenient pipette, will reliably protect your cat from fleas and ticks that carry diseases dangerous to the animal’s health, which not only reduce immunity, but also require expensive treatment. To prevent diseases, Frontline is used at least once a month from April to October, when ticks are most active; in winter, the interval between treatments can be increased to one and a half to two months. The drug is absolutely harmless for adult cats and kittens, as it is not absorbed into the blood. However, when applying Frontline, you should make sure that the animal cannot lick the remnants of the drug from the skin!

COMPOSITION AND FORM OF RELEASE

An insecticidal and acaricidal preparation in the form of a solution for external use, containing fipronil - 9.8% and S-methoprene - 8.8% as active ingredients, and polyvidone and polysorbate as excipients. It is a colorless transparent liquid with a weak specific odor. Available packaged in 0.5 ml polyethylene pipettes with a break-off tip.

PHARMACOLOGICAL PROPERTIES

It has a pronounced contact insecto-acaricidal effect, is active against the preimaginal and imaginal phases of development of lice, fleas, lice and ticks (ixodidae, cheylitella), parasitic on cats. The mechanism of action of fipronil is to block GABA-dependent (GABA-gamma-aminobutyric acid) receptors of parasites, disrupting the transmission of nerve impulses, which leads to paralysis and death of ectoparasites. S-methoprene inhibits juvenile hormone, which promotes the formation of chitin, thereby disrupting the development of fleas at the egg and larval stages. When applied to the skin, the drug is not absorbed, but gradually, over 24 hours, distributed over the surface of the body and, reserved in the sebaceous glands, has a long-term insecticidal and acaricidal effect in places where ectoparasites are localized. In terms of the degree of impact on the body, Frontline Combo is a low-hazard substance (hazard class 4 according to GOST 12.1.007.76), in recommended doses, it does not have a skin-resorptive, sensitizing, embryotoxic, teratogenic or mutagenic effect. In case of contact with eyes, it causes mild irritation.

INDICATIONS

Prescribed to cats to combat fleas, lice, lice and ticks (ixodid, cheylitella).

DOSES AND METHOD OF APPLICATION

Frontline Combo is used externally by topical (Spot On) application to the skin. Before treatment, break off the tip of the pipette, spread the animal’s fur in the back area (between the shoulder blades) and, pressing the pipette, apply the drug to the skin at one or several points. The protective effect of the drug against ixodid ticks in cats lasts up to 3 weeks, against the imago and preimaginal phases of insect development for up to 6 weeks. If the animal is severely affected by lice, fleas, or lice eaters, it is recommended to treat once a month. If the animal is washed more than 2 times a month, it is recommended to reduce the interval between treatments to 3 weeks. It is not recommended to wash animals within 48 hours after treatment with Frontline Combo, or to use other insecticidal and acaricidal agents.

SIDE EFFECTS

Allergic reactions are possible in hypersensitive animals.

CONTRAINDICATIONS

Increased individual sensitivity to the components of the drug. Sick and convalescent animals, as well as kittens under 8 weeks of age, cannot be treated.

SPECIAL INSTRUCTIONS

If there is increased individual sensitivity to the components of the drug and signs of allergic reactions appear, the treatment is stopped, the drug is washed off with water, and antihistamines are given orally. During the procedure with Frontline Combo, you should follow the rules of personal hygiene and safety precautions provided for working with medicinal products for animals. While working with the medicine, you are not allowed to drink, smoke, or eat. If Frontline Combo accidentally gets on the skin or mucous membranes, it should be washed off with a stream of water. After finishing work, wash your hands with warm water and soap. Empty drug pipettes must not be used for household purposes; they must be disposed of with household waste.

STORAGE CONDITIONS

With precautions according to list B. In the manufacturer's packaging, in a dry place, protected from light and inaccessible to children and animals at a temperature of 0 to 25 ° C. Shelf life: 3 years.

pharmachologic effect

The product has an insectoacaricidal effect; it is active against all phases of the development of lice, lice, fleas and ticks that can parasitize dogs.

When the substance enters the animal’s body, it blocks insect receptors and disrupts the functioning of the nervous system, which causes paralysis and subsequent death of the parasites.

Methopropene, contained in Frontline Combo, forms chitin, which disrupts the development of ectoparasites even at the egg stage, so not only adult individuals die, but also unborn parasites. The medicine does not act instantly; when applied to the skin of an animal, it is slowly absorbed, this period may take 1-2 days.

Drug for dogs MERIAL Frontline COMBO S 2-10kg 1 pipette

Frontline Combo refers to combined insectoacaricidal contact action drugs for dogs 2-10 kg. COMPOSITION AND FORM OF RELEASE An insecto-acaricidal preparation in the form of a solution for external use, containing fipronil - 9.8% and S-methoprene - 8.8% as active ingredients, and polyvidone and polysorbate as excipients. It is a colorless transparent liquid with a weak specific odor. Available packaged in 0.67 ml in polyethylene pipettes with a break-off tip.

PHARMACOLOGICAL PROPERTIES It has a pronounced contact insecto-acaricidal effect, is active against the preimaginal and imaginal phases of development of lice, fleas, lice and ticks (ixodic, cheylitella), parasitic on dogs. The mechanism of action of fipronil is to block GABA-dependent (GABA-gamma-aminobutyric acid) receptors of parasites, disrupting the transmission of nerve impulses, which leads to paralysis and death of ectoparasites. S-methoprene inhibits juvenile hormone, which promotes the formation of chitin, thereby disrupting the development of fleas at the egg and larval stages. When applied to the skin, the drug is not absorbed, but gradually, over 24 hours, distributed over the surface of the body and, reserved in the sebaceous glands, has a long-term insecticidal and acaricidal effect in places where ectoparasites are localized. In terms of the degree of impact on the body, Frontline Combo is a low-hazard substance (hazard class 4 according to GOST 12.1.007.76), in recommended doses, it does not have a skin-resorptive, sensitizing, embryotoxic, teratogenic or mutagenic effect. In case of contact with eyes, it causes mild irritation.

INDICATIONS Prescribed to dogs weighing from 2 to 10 kg to combat fleas, lice, lice and ticks (ixodid, cheylitella).

DOSES AND METHOD OF APPLICATION Frontline Combo S is used externally by topical (Spot On) application to the skin. Before treatment, break off the tip of the pipette, spread the animal’s fur in the back area (between the shoulder blades) and, pressing the pipette, apply the drug to the skin at one or several points. The protective effect of the drug against ixodid ticks in dogs lasts for at least 1 month, against adult insects for up to 3 months, from the preimaginal phases of insect development for up to 8 months. If the animal is severely affected by lice, fleas, or lice eaters, it is recommended to treat once a month. If the animal is washed more than 2 times a month, it is recommended to reduce the interval between treatments to 3 weeks. It is not recommended to wash animals within 48 hours after treatment with Frontline Combo, or to use other insecticidal and acaricidal agents.

SIDE EFFECTS Allergic reactions are possible in hypersensitive animals.

CONTRAINDICATIONS Increased individual sensitivity to the components of the drug. Sick and convalescent animals, as well as puppies under 8 weeks of age, cannot be treated.

SPECIAL INSTRUCTIONS In case of increased individual sensitivity to the components of the drug and signs of allergic reactions appear, treatment is stopped, the drug is washed off with water, and antihistamines are given orally. During the procedure with Frontline Combo, you should follow the rules of personal hygiene and safety precautions provided for working with medicinal products for animals. While working with the medicine, you are not allowed to drink, smoke, or eat. If Frontline Combo accidentally gets on the skin or mucous membranes, it should be washed off with a stream of water. After finishing work, wash your hands with warm water and soap. Empty drug pipettes must not be used for household purposes; they must be disposed of with household waste.

STORAGE CONDITIONS With precautions according to list B. In the manufacturer's packaging, in a dry place, protected from light and inaccessible to children and animals at a temperature of 0 to 25 ° C. Shelf life: 3 years.

Dosage

Frontline Combo is suitable for puppies and dogs of different breeds and sizes, you just need to choose the dosage, the table will help with this.

Pet weight (kg)	Pipette volume and designation on packaging	Number of active ingredients in one pipette
Pet weight (kg)	Pipette volume and designation on packaging	Fipronil (mg)	S-methopropene (mg)
2 – 10	0.67 ml (S)	67	60.3
10 – 20	1.34 ml (M)	134	120.6
20 – 40	2.68 ml (L)	268	241.2
40 – 60	4.02 ml (XL)	402	361.8

For animals weighing more than 60 kilograms, you need to use a complex of several pipettes, based on the calculation of 0.067 ml per kg.

Instructions:

Wear disposable gloves.
Break off the tip of the pipette.
Part the pet's fur slightly (at the withers), and then, lightly pressing the pipette, apply the medicine to one or two points.
Throw away the dropper.

For one dose – 1 pipette. Do not bathe your dog for two days after using the medicine. A repeat procedure can be performed no earlier than 3-4 weeks after the first.

Doses and method of administration

Side effects and contraindications

If the product is used incorrectly (exceeding the dosage, used after the expiration date), side effects may occur:

allergic reactions;
vomit;
slight increase in temperature;
refusal to eat.

If you see such symptoms, immediately contact a veterinary clinic. Before use, read the contraindications for the drug. It is better to avoid taking Frontline Combo if:

puppies have not reached 8 weeks of age;
the animal is allergic to the components of the drug;
The dog is suffering from infectious diseases.

Other products in the series

There is a whole series of “Frontline” medications; we will consider each drug separately.

Frontline Nexgard

Delicious (beef flavored) chewable tablets that help quickly get rid of parasites. The tablet begins to act within half an hour after use. One application is enough to forget about ticks/fleas for a whole month.

Frontline Spray

This product is for puppies, kittens and small breeds of animals weighing less than two kilograms. The substance is safe and can be used from the second day of life. The drug is economical and easy to use.

Owner reviews

Tamara, Pumice

“I noticed that the dog began to itch frequently, it turned out to be fleas. I don’t know where he could have picked them up, but the parasites appeared, so he had to look for a way to get rid of them. The veterinary pharmacy recommended an expensive and, as I was told, more effective remedy - Frontline Combo. On the second day after use, I found two dead fleas on the dog’s body and decided that I was done with them. But the dog did not stop itching, and after a couple of days I saw live fleas, I conclude that the money was wasted. I had to go to the vet clinic. The doctor recommended another remedy that relieved the pet of parasites.”

Irina, Moscow

“I chose Frontline Combo because I saw on the packaging that it destroys not only adult parasites, but also their larvae. The price, of course, is steep, but nothing is a pity for your beloved pet. I bought it and applied it to the withers. After two days, I noticed that the dog stopped itching and generally began to look noticeably more cheerful. In general, the medicine helps against fleas well. I recommend!”