MELOXIDIL 10 ml suspension for dogs anti-inflammatory non-steroidal drug

The principle of action of the drug

The therapeutic effect is exerted by the main component of the drug - meloxicam. Its mechanism of action is its ability to suppress the synthesis of cyclooxygenase (COX), which produces inflammatory prostaglandins that cause inflammation, as well as swelling and pain.

Meloxicam is well absorbed from the intestines, as well as:

• already after 7 hours its concentration in the blood reaches the maximum norm;
• the drug accumulates in the liver;
• its main part (about 75%) is excreted in the bile in the form of a metabolite;
• the elimination period is just over a day;
• according to the degree of harm, it belongs to hazard class 4 (low-hazard);
• The therapeutic effect becomes noticeable already on the 3-4th day of use.

Important! You cannot prescribe Meloxidil to your pets on your own. It can only be prescribed by a veterinarian after an examination.

The specialist will assess the severity of the disease and prescribe a drug, as well as determine its dosage.

Analogues and prices

Today, there are many drugs with a similar effect to Meloxidil:

• "Movalis" (533 rubles);
• "Meloxicam" (97 rub.);
• "Amelotex" (177 rubles);
• “Artrosan” (250 rub.);
• “Movasin” (103 rubles), etc.

Despite the higher cost of Meloxidil compared to the above-mentioned drugs, many cat owners still prefer to treat their pets with this medicine. But you need to remember that the decision to treat your pet must be made together with the treating specialist. Health to you and your pets!

Indications for use

"Meloxivet" has an antipyretic effect, eliminates inflammatory processes, reduces pain, and exhibits analgesic activity.

Did you know? Cats can make over a hundred different sounds, while dogs can only make 10.

This allows it to be used to treat the following ailments in animals:

• acute diarrhea;
• colds, acute respiratory infections;
• purulent catarrhal mastitis;
• inflammatory diseases of the musculoskeletal system, including arthritis, arthrosis, synovitis;
• postpartum sepsis;
• fractures, tendon sprains, dislocations;
• degenerative joint diseases;
• inflammatory diseases of soft tissues.

Also, the medication has proven itself as an analgesic and anti-inflammatory agent during the postoperative period and rehabilitation period.

When is it appointed?

This medicine must be taken by animals that have been diagnosed with an inflammatory process in the joints.
Veterinarians prescribe Meloxidil for purring cats to treat acute or chronic pathologies of the musculoskeletal system. The therapeutic effect of the drug extends to arthritis, degenerative-dystrophic joint disease, inflammatory damage to the synovial membrane of a bone joint, and a non-steroidal anti-inflammatory drug is also actively used for dislocations. "Meloxidil" effectively fights inflammation and quickly relieves painful discomfort, significantly alleviating the condition of purrs.

Indications for use

According to the instructions, Loxicom for cats is prescribed as an anesthetic in the following cases:

• for acute or chronic diseases of the joints and spine;
• for fractures, dislocations and other injuries;
• in case of damage to soft tissues (bruises, tissue ruptures with a sharp object, etc.);
• in inflammatory processes of other origin.

The drug can also be used for dental problems or other diseases that are accompanied by severe pain. Loxicom is often prescribed in the postoperative period to relieve fever and prevent swelling, as well as relieve pain. When using the drug, it is easier for the animal to endure the consequences of surgery.

The drug is used exclusively to relieve symptoms. It helps reduce the suffering of the animal during injuries, acute or exacerbation of chronic diseases. In this regard, the medicine is usually used in complex therapy, combined with other medications.

Purpose

Meloxidil can be used as a first aid remedy for injuries - dislocations, fractures, ruptures and sprains. A cat can be injured when falling from a height, which happens when a pet, sitting on a railing, sees a bird and tries to catch it. Often intra-articular injuries (cracks, fractures) are diagnosed. Any disorders of bone tissue are accompanied by pain, and in the future there is a high probability that the animal will suffer from inflammatory processes in the joints - arthritis, arthrosis.

It is not always possible to immediately determine which part of the body is injured. If a cat drags its hind legs, it can suffer both limb injuries and dangerous spinal fractures. Therefore, it is important to show your pet to a specialist as soon as possible: if the spine is injured, it is important to start treatment immediately, but even in this case, it is not always possible to guarantee a favorable prognosis.

Injuries often occur when cats fight with each other or with dogs. Injuries can be single or multiple, for example, bone fractures combined with bruises of internal organs. Only a veterinarian can assess the extent of damage, and Meloxidil can relieve pain and alleviate the pet’s condition before visiting the veterinary clinic and prescribing treatment.

In addition, the drug is often included in complex therapy for chronic and acute diseases of the musculoskeletal system: arthritis, synovitis, arthrosis, etc. Meloxidil will help relieve pain in the postoperative period during surgical interventions on the joints, and prevent the development of secondary infections.

Joint diseases in cats

Arthritis and arthrosis are two different diseases. The first is an inflammatory process in the joints, which is accompanied by:

• soreness of the affected joint;
• local and general increase in temperature;
• fever.

The most common sign of pathology in a cat is an unusual gait: when the pet walks on the floor, knocking its claws, or stomping loudly. Inflammatory joint disease is common in older cats, and some breeds have a genetic predisposition to joint disease. These include Maine Coons, British cats and some others. Often the inflammatory process develops after injury. Damage to the joints received in childhood may not appear for a long time, but with age it will remind itself of arthritis.

Signs of joint inflammation in cats are:

• decreased mobility, caution when jumping;
• lameness;
• refusal to play, communicate with people, other animals;
• changes in grooming – a sick cat grooms itself less, and its coat becomes dull;
• excessive licking of the sore joint.

The danger of arthritis is that owners cannot always notice lameness and stiffness of movement in a cat that sleeps most of the day. Therefore, inflammation often affects a large area of ​​tissue and complicates treatment.

Depending on the causes of inflammation, veterinarians distinguish several types of arthritis. An infection is caused by the penetration of pathogenic bacteria into the body, which enter the joint through the bloodstream, causing an inflammatory process. The causes of infection can be trauma or surgery. With septic arthritis, a cat experiences lameness, swelling, and stiffness of movement. An x-ray may show a buildup of synovial fluid in the diseased joint. In this case, painkillers alone are not enough; treatment includes the use of antibiotics.

The actions of a cat's own immune system can cause immune-mediated arthritis. Most often it affects several joints, causing lameness, swelling and pain. In some cases, the pet experiences destruction of cartilage tissue and bones.

Cancer arthritis is a dangerous disease that is caused by the presence of a malignant tumor – synovial cell sarcoma. In a quarter of cases, cancer cells spread to the lungs; sometimes such consequences can only be avoided by amputating the affected limb.

Arthrosis is an “age-related” disease, a destructive pathology characterized by gradual destruction of the joint. The development of the disease begins with a decrease in the volume of synovial fluid in the joint capsule, and the cartilage tissue gradually begins to break down. The very last stage begins when the cartilage layer is thinned to such an extent that the joints begin to rub against each other. This causes severe pain in the cat, and she tries to move as little as possible so as not to experience discomfort.

The causes of arthrosis can be:

• injuries - even old joint injuries can eventually come back to haunt you with a painful pathology;
• disruption of metabolic processes in the pet’s body;
• excess weight, which increases stress on the joints.

Arthrosis cannot be treated; the cat will have to live with pain all its life, since damaged cartilage and joints cannot be restored with any medications. Meloxidil is prescribed to relieve pain and, as far as possible, to improve the quality of life of a sick animal.

Negative effects

Correct use of the medicine is the key to successful and safe treatment. By neglecting the recommended doses and contraindications, the owner exposes the purr to various side symptoms. Thus, during therapy with Meloxicam, a cat may develop the following undesirable effects:

Drowsiness in a fluffy is a side effect of treatment with this drug.

• allergic reaction;
• drowsiness;
• cardiopalmus;
• blood pressure surges;
• abdominal pain;
• leukopenia;
• itching, rashes on the skin;
• swelling;
• disorders of the kidneys and liver.

Long-term use of Meloxicam should be carried out exclusively under the supervision of a veterinarian. If an allergic reaction occurs in a cat, as a result of the body’s increased personal sensitivity to the components of the drug, treatment is stopped and the purr begins to be given antihistamines. The remaining symptoms usually go away on their own immediately after stopping the medication.

How can I replace Loxicom?

The formulas of veterinary analogues of Loxicom are also based on meloxicam, which is the main active ingredient of these drugs and provides a similar effect on the cat’s body. Loxicom analogues are usually used to save money - these products are cheaper. The average cost of Loxicom ranges from 900 to 1000 rubles per 15-milliliter bottle.

Table: overview of analogues of the drug Loxicom

Chemical composition of the drug "Meloxidil"

The main active ingredient of this product is meloxicam (0.15 g per 100 ml). In addition, the drug contains:

• xanthan gum;
• sorbitol;
• colloidal silicon;
• xylitol;
• sodium benzoate;
• glycerol;
• citric acid;
• distilled water.

Did you know? There are up to 230 bones in a cat's body (humans have 206). The animal's ability to fit into any hole corresponding to the size of its head is explained by its lack of collarbones.

Contraindications and side effects

In doses prescribed by a specialist, the drug is well tolerated by cats.

Important! Side effects occur most often at the beginning (the first 7 days) and disappear after stopping use.

But you should stop taking it and contact your veterinarian if your pet develops the following symptoms:

• he vomits;
• the animal has an upset stomach;
• black or bloody stools;
• coordination of movements is impaired;
• attacks of aggression appeared;
• low or too high activity;
• changes in the color of urine or mucous membranes.

You cannot start treatment with the drug if the animal has the following problems:

• duodenal or gastric ulcer;
• heart failure;
• hemorrhagic syndrome;
• renal failure;
• liver diseases;
• individual intolerance.

The use of the medication is also prohibited:

• during pregnancy and lactation of cats;
• kittens up to 6 weeks of age;
• together with non-steroidal anti-inflammatory drugs, anticoagulants, diuretics and medications with a high degree of binding to serum proteins (increases the likelihood of increased toxicity).

If the dose is exceeded, the following may occur:

• diarrhea;
• vomit;
• in the future - the development of gastritis or ulcers.

Overdose

Meloxidil is only dangerous if the dose is greatly exceeded. Excessive amounts of meloxicam in a dog's body can lead to indigestion, gastritis and peptic ulcers.

If you follow the rules for taking the drug, no side effects are observed, in extremely rare cases the following are observed:

• refusal of food;
• diarrhea;
• nausea and vomiting;
• blood in stool.

Important! The medicine cannot be combined with some medications, so it cannot be used for self-medication.

How to use Loxicom correctly

Before each use, the bottle of Loxic should be shaken several times to restore the homogeneity of the suspension. It is most convenient to pour the medicine into the cat’s mouth using the dispenser syringe included with the package - this will allow you to accurately measure the required volume of the drug. If necessary, you can replace this dispenser with a regular disposable syringe, after first removing the needle from it.

Some owners prefer to mix a dose of Loxicom into their pet's food: wet food or natural food. Cats eat this medicinal portion without any problems. This method of giving medicine to an animal has a right to exist, especially since the instructions recommend giving the cat Loxicom during meals.

Dosages and treatment regimens

Loxicom is a powerful drug that can both cure an animal and harm it if used incorrectly. Therefore, only a veterinarian should prescribe Loxicom, having previously examined the sick cat and given it an accurate diagnosis. You must strictly follow medical recommendations and not self-medicate.

Table: optimal therapeutic dosages of Loxicom

The course of treatment with Loxicom should not exceed ten days. If no significant improvement occurs during this time, stop taking the drug.

To achieve the best therapeutic effect, it is very important not to violate the regular use of Loxicom, use it according to the schedule and not miss a single dose

It is important to follow the dosage and treatment regimen of Loxicom

Features of use in kittens and pregnant cats

A veterinarian can prescribe Loxicom to pregnant and lactating cats only for health reasons and in a light dosage - the drug can be dangerous both for the female and for her offspring. Correctly selected doses of the drug for treating a pregnant cat allow it not to accumulate in the body and not have a negative effect on the embryos.

Doctors use the same approach when treating kittens younger than one and a half months old - they are prescribed Loxicom only in extreme cases, and the dose is usually halved.

Contraindications and side effects of the drug

There will be no side effects with Loxicom if you do not exceed the dosage of the drug and do not use it with obvious contraindications:

• immunity to meloxicam;
• pathologies of the stomach and duodenum - ulcer or acute gastritis;
• kidney diseases;
• liver failure;
• haemorrhoids.

A cat may need serious treatment if the owner voluntarily allowed the dosage of Loxicom to be exceeded - it is no coincidence that this drug is considered a moderately dangerous drug. Take this moment responsibly and immediately consult a doctor as soon as you notice that your pet has the following symptoms:

• nausea and vomiting;
• diarrhea;
• sudden loss of appetite;
• general weakness and apathy;
• speckles of blood in the stool.

Treatment with Loxicom should be under the supervision of a veterinarian

Interaction with other drugs

Considering the likelihood of a depressing toxic effect of Loxicom on the kidneys, this drug should not be used in parallel with other medications (both veterinary and human) that can enhance this negative effect:

• glucocorticosteroids - steroid hormones;
• diuretics - diuretics;
• anticoagulants - drugs that thin the blood;
• aminoglycosides are organic antibacterial drugs.

Storage conditions and shelf life of Loxicom

Loxicom can retain all its properties for two years. From the moment the bottle is opened, the shelf life of the drug is reduced to six months. It is strictly forbidden to use the drug after its expiration date - the expired suspension should be poured out and the bottles should be thrown away; they should not be left for any household purposes.

The following storage rules for Loxicom must be strictly observed:

• do not freeze;
• observe the temperature regime from 0 to 25 degrees Celsius;
• the storage location should be dry and protected from bright sunlight;
• keep separately from animal feed and food;
• keep away from children and pets.

Instructions for use of the drug in veterinary medicine

If your cat has been prescribed Meloxidil, you need to carefully read the product label and also adhere to certain rules :

• During storage, sediment may appear, so the bottle must be shaken before use;
• the drug is given once a day and preferably at the same time;
• the medicine is given to the pet along with food;
• on the first day of administration, the dose is 0.2 mg of the active substance per kilogram of animal weight;
• in the following days, the volume of the medicine is two times lower - 0.1 ml/kg;
• the duration of the treatment course is prescribed by a specialist, but on average it is 10 days;
• To measure the exact dose, you need to use the dispenser syringe included in the package. 1 division of the smaller syringe corresponds to 0.5 kg of the pet’s weight, and 1 division of the larger one corresponds to 2.5 kg of weight. This amount contains the daily dose of the active drug;
• After 10 days of treatment, the animal must be re-examined by a veterinarian.

Video: how to give injections to cats

Possible restrictions

The drug is contraindicated in animals with a history of gastric and duodenal ulcers.
Despite the maximum safety of Meloxicam for cats, manufacturers provide a list of contraindications, in the presence of which the medicine should be discarded. Thus, a non-steroidal anti-inflammatory drug is not suitable for cats with individual intolerance to any component of its composition. In addition, you cannot use Meloxicam if your pet has been diagnosed with ulcerative lesions of the stomach and duodenum, hemorrhagic syndrome, or severe impairment of the functioning of the kidneys and liver.

You should not combine Meloxicam with glucocorticosteroids, anticoagulants and other non-steroidal anti-inflammatory drugs. Veterinarians do not prescribe this medication to lactating and pregnant females, kittens under 6 weeks of age, or purring cats with dehydration, low blood pressure, and reduced circulating blood volume. In exceptional cases and only at the discretion of the veterinarian, such animals may be prescribed Meloxicam, but only in a dosage half the usual one. It is strictly forbidden to treat cats with this medicine that have diseases of the cardiovascular system, there is a threat of developing stomach ulcers and gastrointestinal bleeding.

Meloxidil 1.5 mg/ml 10 ml

COMPOSITION AND FORM OF RELEASE

As an active ingredient, 100 ml of Meloxidil contains 0.15 g of meloxicam, and as excipients xanthan gum 0.20 g, anhydrous colloidal silicon 2.00 g, sorbitol 30.00 g, glycerin 16.00 g, xylitol 15, 00 g, sodium benzoate 0.20 g, citric acid to pH 4.0 and water to 100 ml.

In appearance, Meloxidil is a light yellow suspension. During storage, the formation of sediment is allowed, which, when shaken, forms a uniform suspension.

Meloxidil is produced packaged in 10, 32 and 100 ml in polymer bottles of appropriate capacity, which are packaged in cardboard boxes and supplied with two measuring syringes, designed for dogs weighing up to 7 kg and dogs weighing more than 7 kg.

PHARMACOLOGICAL PROPERTIES

Meloxicam, part of Meloxidil, belongs to the oxicam group of NSAIDs and has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action of meloxicam is to suppress the production of cyclooxygenase (COX) in the arachidonic acid cycle, while the production of COX-II is predominantly suppressed, under the influence of which the synthesis of inflammatory prostaglandins (PGE1 and PGE2) occurs, causing inflammation, swelling and pain.

After oral administration, meloxicam is well absorbed from the intestines of dogs and reaches its maximum plasma concentration within 7.5 hours, with a half-life of 24 hours. Meloxicam is metabolized in the liver and excreted in bile (75%) as a metabolite of glucuronic acid.

In terms of the degree of impact on the body, Meloxidil is classified as a low-hazard substance (hazard class 4 according to GOST 12.1.007-76).

INDICATIONS

Meloxidil is used in dogs to treat inflammation in acute and chronic diseases of the musculoskeletal system (arthritis, arthrosis, dislocations, edema, synovitis, tenosynovitis).

DOSES AND METHOD OF APPLICATION

Meloxidil is administered orally with food once a day at a dose of 0.2 mg/kg meloxicam on the first day of treatment, then at a maintenance dose of 0.1 mg/kg meloxicam for 10 days.

Before use, shake the contents of the bottle until a homogeneous suspension is formed.

Each package is equipped with two measuring syringes, which allows you to dose the drug as accurately as possible for small and large breeds of dogs. One division of a small syringe is designed for 0.5 kg of animal weight, a large syringe is designed for 2.5 kg of animal weight, which corresponds to a daily maintenance dose of 0.1 mg/kg of meloxicam.

The clinical effect occurs 3-4 days after starting to use the drug. The duration of the course of treatment is determined by the veterinarian depending on the indications.

After a 10-day course of treatment, the animal must be examined by a veterinarian and if there is no improvement in the clinical condition, the use of the drug is stopped.

An overdose of Meloxidil in dogs by five times or more leads to dysfunction of the mucous membrane of the gastrointestinal tract (ulcers, gastritis), manifested by vomiting and diarrhea.

In case of drug overdose, symptomatic treatment is recommended.

The use of the drug in animals in a state of dehydration, hypovolemia and hypotension is potentially dangerous due to the possible toxic effect of meloxicam on the kidneys.

In case of emergency, when prescribing Meloxidil to such animals, the daily dose should be halved and the clinical condition should be carefully monitored.

If one or more doses of the drug are missed, treatment should be resumed as soon as possible in the prescribed dosage and regimen.

SIDE EFFECTS

At recommended doses, the drug is well tolerated by dogs. In rare cases, possible: loss of appetite, apathy, vomiting, diarrhea, hidden blood in feces.

Side effects usually appear in the first week of treatment and in most cases go away on their own after discontinuation of the drug.

CONTRAINDICATIONS

Individual hypersensitivity to meloxicam, gastric and duodenal ulcers, hemorrhagic syndrome, severe cardiac, hepatic and renal failure, pregnancy and lactation, age up to 6 weeks.

SPECIAL INSTRUCTIONS

It is not recommended to use Meloxidil in combination with other NSAIDs, glucocorticoids, diuretics, anticoagulants, aminoglycoside antibiotics and other drugs that are characterized by a high degree of binding to serum proteins due to the likelihood of increasing the toxic effect of the drug. If treatment with other NSAIDs is ineffective, Meloxidil is prescribed no earlier than 24 hours after discontinuation of the previous drug under the supervision of a veterinarian.

The drug is not intended for the treatment of productive animals.

Personal prevention measures

When working with Meloxidil, you should follow the general rules of personal hygiene and safety precautions provided for when working with medicines.

When treating an animal with a medicinal product, contact with eyes and skin should be avoided; smoking, drinking and eating should not be allowed.

If the drug accidentally comes into contact with the skin or mucous membranes of the eyes, they must be rinsed with water. People with hypersensitivity to NSAIDs should avoid direct contact with Meloxidil. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label).

Empty bottles of the drug must not be used for household purposes; they are disposed of with household waste.

STORAGE CONDITIONS

In the manufacturer's sealed packaging, in a dry place, protected from light and inaccessible to children and animals, separately from food and feed at a temperature of 0°C to 25°C. Shelf life in unopened packaging, subject to storage conditions, is 3 years from the date of manufacture. After opening the bottle, the drug can be used for 6 months.

It is prohibited to use the medicine after the expiration date.

Unused drug is disposed of in accordance with legal requirements.

Similar medical products

If for some reason it is impossible to use Meloxicam, veterinarians replace it with another medication, but with a similar effect on the cat’s body. Thus, an absolute analogue is Meloksivet, which also belongs to the group of NSAIDs, but is also an antirheumatic drug, which makes it popular in the treatment of inflammatory diseases of the musculoskeletal system in cats. Meloksivet is also used to cure respiratory infections, in combination with antibacterial therapy in the fight against purulent catarrhal mastitis. Another analogue is the “Loxic” oral suspension, which is no less effective in relieving inflammation, relieving pain and normalizing body temperature.

Description and characteristics

"Meloxidil" is a non-steroidal drug that has anti-inflammatory, analgesic and antipyretic effects for diseases of the musculoskeletal system in pets. The manufacturer's annotation states that the medication is used to treat dogs, but veterinarians also prescribe it for cats, rabbits and ferrets. It is effective in both chronic and acute forms of diseases. This product cannot be called cheap; its price ranges from 1000 rubles. for 10 ml. But, judging by the reviews of animal owners, it justifies itself.