Pharmacodynamics and pharmacokinetics
Ringer-Locke solution is capable of regulating the water-salt and acid-base balance in the human and animal body. The product is closest to the natural composition of blood plasma . The drug inhibits the processes of aggregation blood elements and improves tissue perfusion .
Electrolytes thin the blood, and glucose prevents the development of hypoglycemia .
Very quickly after injection, the drug is distributed to organs and tissues.
Composition, release form
Ringer-Locke solution (the price of the product is affordable for most patients) is a clear, colorless liquid without a specific aroma. It is packaged in special dark glass bottles of 200 ml. You can also find bottles of 100, 250, 400 ml. In each case, the patient can purchase the volume he needs.
The product contains several active ingredients, which provide the main effect on the body:
- Sodium chloride in quantity.
- Potassium chloride.
- Calcium chloride.
- Glucose in small quantities.
The solution contains prepared water for injection as an auxiliary ingredient.
Indications for use
The drug is prescribed:
- during dehydration and severe intoxication of the body due to dysentery , food poisoning, diarrhea and vomiting, El Tor cholera ;
- if dehydration occurs due to circulatory disorders, severe blood loss;
- for burns, frostbite, shock ;
- if inflammation of the peritoneum develops - peritonitis .
Ringer-Locke solution is also used for animals with similar symptoms, albeit in a different dosage.
Contraindications and side effects
Ringer-Locke solution is not used when the patient experiences individual negative reactions. The price of the medicine allows you to complete a full course if necessary, but if complications occur, you should abandon therapy.
Contraindications include the following conditions:
- Edema of the lungs or brain. With such a violation, the drug can provoke the progression of symptoms.
- Severe form of heart failure. The medication increases the volume of circulating blood, so patients with this disorder may experience negative symptoms.
- Acidosis of varying severity.
- Increased levels of calcium, potassium and sodium in the blood. The presence of such components in the solution may aggravate kidney symptoms.
- Acute or chronic renal failure, accompanied by anuria or oliguria. The use of medication often provokes a deterioration in the general condition and the appearance of systemic disorders.
- Acute internal bleeding. After eliminating acute manifestations, the solution can be used to alleviate the condition.
Patients may have individual contraindications, which are determined during a diagnostic examination. The official instructions indicate that during pregnancy and lactation the medication can be used according to indications and under the supervision of a doctor.
The solution is also prescribed to children without restrictions, but the doctor monitors the condition, and the dosage is determined individually depending on age and body weight.
Ringer-Locke solution (the price of the product may vary depending on the volume of the bottle) rarely provokes complications from internal organs. Despite this, patients sometimes report individual allergic reactions. They manifest themselves with standard symptoms in the form of a rash on the body, severe itching and burning.
The rash can spread to large areas of the skin, causing skin irritation. Sometimes allergies provoke swelling of the mucous membranes of the throat, mouth, and eyes. Patients report watery eyes and temporary blurred vision.
Symptoms may worsen, leading to suffocation. Such disorders threaten not only the health, but also the life of the patient. If they appear, you should immediately tell your doctor. Ignoring symptoms or using any remedies on your own is strongly discouraged.
In case of an acute allergic reaction, the patient requires complex treatment using medications from different groups. Long-term treatment with the solution provokes an increase in the level of calcium, sodium and potassium in the blood, which negatively affects the functioning of the central nervous system and internal organs.
Interaction
Caution should be used when combining the medicine with certain drugs, such as NSAIDs , estrogens or anabolic steroids .
When combined with cardiac glycosides, the load on the cardiovascular system increases.
Concomitant use with diuretics , angiotensin-converting enzyme or potassium supplements can lead to hyperkalemia .
Instructions for use
The drug is used only for parenteral administration after a preliminary examination by a doctor. Depending on the disease, the treatment regimen may differ. For each patient, the dosage and duration of use is determined individually.
| Disease | Scheme for using the solution |
| State of shock | In case of such a violation, the patient is administered 20 ml of solution per day. The infusion is carried out slowly using a dropper, which avoids the development of negative reactions during manipulation. The duration of the therapeutic course does not exceed 5 days. Usually this time is enough to obtain a pronounced therapeutic effect. In severe cases, when the patient's condition is critical, the solution can be administered intravenously in a slow stream using a syringe. Such manipulations are usually carried out once, after which the solution is administered in the standard way using a dropper. |
| Dehydration due to infectious diseases | For such disorders, the patient usually needs 3 days of intensive therapy using the solution. The drug is administered intravenously slowly to provide a mild effect on the body. The daily norm for a patient is 200-400 ml. During treatment, the doctor monitors the patient’s condition and, if necessary, adjusts the dose and duration of the course. |
| Poisoning of the body | An important point in the treatment of poisoning in patients is the administration of drugs in a timely manner. Otherwise, the therapeutic effect occurs later, complications develop more often. On the first day after the onset of symptoms, the patient is prescribed 200 ml of solution, administered slowly using a dropper. If there is no effect, the dose is increased to 400 ml per day. Sometimes it is necessary to prescribe an increased dosage, which reaches 1000 ml, but the doctor makes the decision after examining the patient. The duration of the treatment course usually does not exceed 5 days. |
| Burns and frostbite | The remedy for severe forms of burns and frostbite is prescribed in courses of 5-7 days with daily administration of 400-800 ml of solution according to the standard regimen. If the patient's weight exceeds 100 kg, the daily dosage can be increased to 1000-1200 ml, which allows achieving a more pronounced result. When infusing drips, the speed should not exceed 60 drops/min. |
When prescribing medication for children, the patient's weight is usually taken into account. The daily dosage is no more than 10 ml per 1 kg of weight. Children under 2 years of age are prescribed no more than 5 ml per 1 kg of weight. The duration of therapy for children is determined depending on their condition. In most cases, 3-4 days are enough to eliminate acute symptoms.
The result of therapy depends on the patient’s condition and the agents used simultaneously with the solution. Experts note that the medicine is used in a hospital setting. This allows complications to be detected during treatment in a timely manner and eliminated.
Analogs
Level 4 ATC code matches: Disol
Sterofundin
Trisol
Ringer's solution
Gik, Glyukosol, Darrow, Glycosteril, Acesol, Yonosteril, Ringer's solution, Disol, Trisol, Chlosol, Saline solution.
Price of Ringer-Locke solution
The cost of Ringer-Locke solution is 40 rubles per 200 ml.
The price of a 100 ml bottle (for animals) is about 20 rubles.
Education: Graduated from Rivne State Basic Medical College with a degree in Pharmacy. Graduated from Vinnitsa State Medical University named after. M.I. Pirogov and internship at his base.
Work experience: From 2003 to 2013 – worked as a pharmacist and manager of a pharmacy kiosk. She was awarded diplomas and decorations for many years of conscientious work. Articles on medical topics were published in local publications (newspapers) and on various Internet portals.
Instructions for medical use of the drug RINGER-LOCKE solution (Solutio Ringer - Locke)
Active ingredients: sodium chloride 9.0 g, potassium chloride 0.2 g, calcium chloride 0.2 g, sodium bicarbonate 0.2 g, glucose monohydrate 1.0 g (in 1 liter of the drug);
excipients: water for injection.
Dosage form
. Solution for infusion.
Pharmacotherapeutic group
. Blood substitutes and perfusion solutions. Electrolytes with carbohydrates.
ATS code
В05ВВ02.
Indications
. Dehydration of various origins, acute massive blood loss, shock, extensive burns, severe postoperative period, intoxication of various etiologies. Ringer-Locke solution is also used as a detoxification agent. Externally - for diseases of the eyes, nose, mucous membranes, for washing wounds.
Contraindications
. Intravenous administration of Ringer-Locke solution is contraindicated in thrombophlebitis, conditions with increased blood clotting, severe impairment of renal excretory function, and decompensated heart defects. The drug should not be administered in case of circulatory disorders that can cause cerebral and pulmonary edema, hyperchloremia, hypernatremia, hyperhydration, metabolic alkalosis, hypertensive dehydration.
Directions for use and doses
. Prescribed intravenously, rectally and externally. Intravenous Ringer-Locke solution is prescribed dropwise at a rate of 4-8 ml/kg/h: for adults - in a volume of 50 ml to 1 liter per day, for children - 10-20 ml/kg per day, depending on the severity of the disease. Rectally, the drug is prescribed to adults and children, 75-100 ml in the form of enemas, externally - for diseases of the eyes, nose, mucous membranes, for washing wounds.
Adverse reactions
. Chloride acidosis, overhydration.
Overdose
. Overhydration, hypernatremia, hypercalcemia, alkalosis, hyperchloremia. Treatment is symptomatic.
Use during pregnancy or breastfeeding
. The drug is used for health reasons and taking into account the risk/benefit ratio.
Children
. Can be used in children.
Features of application. With long-term use, especially in large volumes, monitor the content of electrolytes (in plasma, urine) and diuresis
Use with caution in patients with impaired renal excretory function
The ability to influence the reaction rate when driving vehicles or other mechanisms
. Does not affect.
Interaction with other drugs
. Ringer-Locke solution can be used simultaneously with blood transfusions and blood plasma transfusions to increase the effectiveness of infusion therapy.
Pharmacodynamics. Ringer-Locke solution is a saline plasma replacement fluid. It contains a balanced (isotonic) mixture of the main ions (Na+, K+, Ca+, Cl-, HCO3-) of the blood in appropriate concentrations. The administration of Ringer-Locke solution restores the water-salt balance and eliminates fluid deficiency in the human body, which occurs during dehydration or due to the accumulation of extracellular fluid in areas of extensive burns and injuries, abdominal operations, and peritonitis. Ringer-Locke solution reduces the aggregation of formed elements and blood viscosity, improves its rheological properties and tissue perfusion, which prevents the development of irreversible changes in tissues and increases the effectiveness of blood transfusions in cases of massive blood loss and severe forms of shock. Ringer-Locke solution also has a detoxification effect due to a decrease in the concentration of toxic products in the blood and activation of diuresis.
Pharmacokinetics. Not studied.
Basic physical and chemical properties: transparent, colorless or slightly yellowish solution.
Best before date
. 2 years.
Storage conditions
. In a place protected from light at a temperature of 15ºС to 25ºС. Keep out of the reach of children.
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